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19-147

U0126

Name: U0126
Brand: MM

solid, suitable for kinase activity assay

Synonim(y):

Inhibitor MEK, Inhibitor kinazy

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Informacje o tej pozycji

UNSPSC Code:

12352200

NACRES:

NA.41

eCl@ss:

32160405

Pomoc techniczna

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Właściwości

Nazwa produktu

U0126, U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Quality Level

100

form

solid

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_002755.2

UniProt accession no.

P36507, Q02750

shipped in

wet ice

Gene Information

human ... MAP2K1(5604)

Opis

Biochem/physiol Actions

Inhibitor Type: Kinase

Protein Target: MAPKK 1

Physical form

C₁₈H₁₆N₆S₂

Preparation Note

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Klasa składowania

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids.

Jahangir Iqbal et al.

The Journal of biological chemistry, 295(13), 4101-4113 (2020-02-13)

The hormone leptin regulates fat storage and metabolism by signaling through the brain and peripheral tissues. Lipids delivered to peripheral tissues originate mostly from the intestine and liver via synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins. An intracellular chaperone

Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes.

Scherle, P A, et al.

Journal of immunology (Baltimore, Md. : 1950), 161, 5681-5686 (1998)

Pseudomonas aeruginosa Stimulates Inflammation and Enhances Kaposi's Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin.

Ashley Markazi et al.

mBio, 11(6) (2020-11-12)

Inflammation triggered by innate immunity promotes carcinogenesis in cancer. Kaposi's sarcoma (KS), a hyperproliferative and inflammatory tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV) infection, is the most common cancer in AIDS patients. KSHV infection sensitizes cells to pathogen-associated molecular patterns

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19-147	08436037123702