164598

Aminopeptydaza M, nerka świńska

• Synonim(y): Aminopeptydaza M, Aminopeptydaza N, Aminopeptydaza alanylowa
• Numer CAS: 9054-63-1
• Numer WE: 3.4.11.2 (BRENDA, IUBMB)
• UNSPSC Code: 12352202
• NACRES: NA.54
• MDL number: MFCD00131501
• Biological source: Porcine kidney

Właściwości

• biological source: Porcine kidney
• Quality Segment: 100
• form: suspension (crystalline)
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: physiological buffer: soluble, water: soluble
• foreign activity: Oxidases ≤3%
• shipped in: ambient
• storage temp.: 2-8°C

Opis

General description

Aminopeptidase M (APM) is abundantly found in brush border membranes of the kidney, small intestine, placenta, and liver. It is a type II integral membrane protein, known as ectoenzyme.

Application

Aminopeptidase M, porcine kidney has been used:

• to test and identify the peaks containing d-residue in the allatotropin-related peptide (ATRP)
• to study its oxidative inactivation of enzyme activity, and to screen MIRA ingredients
• for the proteolysis of isolevuglandins (IsoLGs) proteins

Biochem/physiol Actions

Aminopeptidase M (APM) is implicated in terminating the actions of certain neuropeptides, like the enkephalins and angiotensin III in the brain. It also metabolizes specific vasoactive peptides. It functions as a receptor for certain viruses, such as coronavirus 229E. APM is a nonspecific peptidase, which rapidly breaks down l-residue peptides.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

Crystalline suspension in 3.2 M (NH₄)₂SO₄, 10 mM MgCl₂, 10 mM Tris-HCl, pH 7.5.

Other Notes

One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of Leu-pNA per min at 37°C, pH 7.2.

Wachsmuth, E.E., et al. 1966. Biochemistry5, 169.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable