14-528-M

MEK2 Protein, active, 250 µg

• Kod UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Właściwości

• rekombinowane: expressed in baculovirus infected Sf21 cells
• Poziom jakości: 300
• opis: protein target MEK2
• oczyszczone przez: (Ni²⁺/NTA-agarose)
• metody: activity assay: suitable
• numer dostępu UniProt: P36507
• informacje o genach: human ... MAP2K2(5605)

Opis

Opis ogólny

FUNCTION: SwissProt: P36507 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
SIZE: 400 amino acids; 44424 Da
SUBUNIT: Interacts with MORG1 (By similarity).
PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
DISEASE: SwissProt: P36507 # Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
SIMILARITY: SwissProt: P36507 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.

Opakowanie

Also available in 10 μg size (cat#14-528) and in bulk (cat# 14-528-K).

Jakość

routinely evaluated by phosphorylation of unactive MAP Kinase 2/Erk2

Właściwości fizyczne

46kDa

Przechowywanie i stabilność

6 months at -70°C

Komentarz do analizy

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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