14-404-M
ZAP-70 Protein, active, 20 µg
Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.
Synonim(y):
70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase
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About This Item
Kod UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32
pochodzenie biologiczne
human
Poziom jakości
rekombinowane
expressed in Sf21 cells
Postać
liquid
okres trwałości
6 mo.
masa cząsteczkowa
Mw 70 kDa
producent / nazwa handlowa
Upstate®
metody
activity assay: suitable (kinase)
numer dostępu NCBI
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... ZAP70(7535)
Opis ogólny
Research area: CELL SIGNALING
Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag
Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag
Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Działania biochem./fizjol.
Protein Target: ZAP-70
Target Sub-Family: TK
Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Target Sub-Family: TK
Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Jakość
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide
Postać fizyczna
Ni2+/NTA-agarose
Przechowywanie i stabilność
6 months at -20C
Inne uwagi
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informacje prawne
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Experimental Models for Rheumatoid Arthritis
Rikard Holmdahl
Journal of Separation Science, 400-412 (2013)
ZAP-70: an essential kinase in T-cell signaling
Wang H, et al.
Cold Spring Harbor Perspectives in Biology, 2(5), a002279-a002279 (2010)
The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
Huber RG, et al.
PLoS Computational Biology, 11(10), e1004560-e1004560 (2015)
ZAP-70 in Signaling, Biology, and Disease
Au-Yeung BB, et al.
Annual Review of Immunology, 36, 127-156 (2018)
D H Chu et al.
Immunological reviews, 165, 167-180 (1998-12-16)
The processes of T-cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules are shared between the receptor signaling pathways, including two families of cytoplasmic protein
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