04-1552

Anti-TLS Antibody, clone 1FU-1D2

ascites fluid, clone 1FU-1D2, from mouse

• Synonim(y): 75 kDa DNA-pairing protein, FUS-CHOP fusion protein, FUS-CHOP protein fusion, Fusion gene in myxoid liposarcoma, Oncogene FUS, Oncogene TLS, Translocated in liposarcoma protein, fus-like protein, fus/tls-chop oncogene, fusion (involved in t(12, 16) in ma
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: ascites fluid
• rodzaj przeciwciała: primary antibodies
• klon: 1FU-1D2, monoclonal
• reaktywność gatunkowa: human, rat, mouse
• metody: immunocytochemistry: suitable; western blot: suitable
• izotyp: IgG1κ
• numer dostępu NCBI: NP_004951.1
• numer dostępu UniProt: P35637
• Warunki transportu: dry ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... FUS(2521)

Opis

Opis ogólny

The TLS/FUS protein contains an RNA-recognition motif and is a component of nuclear riboprotein complexes. It resembles a transcription factor in that it binds DNA, contributes a transcriptional activation domain to the FUS-ERG oncoprotein, and interacts with several transcription factors in vitro. It binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. It may play a role in maintenance of genomic integrity.

Specyficzność

This antibody recognizes TLS.

Immunogen

Epitope: Unknown

Linear peptide corresponding to human TLS.

Zastosowanie

Immunocytochemistry Analysis:
1:500 dilution from a representative lot detected TLS in C2C12 cells.

Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Transcription Factors

Use Anti-TLS Antibody, clone 1FU-1D2 (Mouse Monoclonal Antibody) validated in WB, ICC to detect TLS also known as 75 kDa DNA-pairing protein, FUS-CHOP fusion protein.

Jakość

Evaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected TLS on 10 µg of HepG2 cell lysate.

Opis wartości docelowych

Observed at 65 kDa

Postać fizyczna

Unpurified

Unpurified mouse monoclonal IgG1κ preservative-free ascites.

Przechowywanie i stabilność

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Komentarz do analizy

Control
HepG2 cell lysate

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): nwg
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable