A-911

7-Aminoflunitrazepam solution

Name: 7-Aminoflunitrazepam solution
Brand: CERILLIAN

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₆H₁₄FN₃O

Numer CAS:

34084-50-9

Masa cząsteczkowa:

283.30

NACRES:

NA.24

PubChem Substance ID:

329771032

UNSPSC Code:

41116107

EC Number:

200-835-2

MDL number:

MFCD00798466

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InChI key

LTCDLGUFORGHGY-UHFFFAOYSA-N

InChI

1S/C16H14FN3O/c1-20-14-7-6-10(18)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)17/h2-8H,9,18H2,1H3

SMILES string

FC1=CC=CC=C1C2=NCC(N(C)C3=CC=C(N)C=C23)=O

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE^®, SNAP-N-SHOOT^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

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Powiązane kategorie

Certified Reference Materials

Controlled Substances & Illicit Drug Standards

General description

As a major metabolite of flunitrazepam, 7-aminoflunitrazepam is a biomarker for use of the parent drug. Flunitrazepam is an intermediate-acting benzodiazepine, typically used in the treatment of severe insomnia. This certified solution standard is suitable for numerous GC/MS or LC/MS testing applications in forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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related product

Numer produktu

Opis

Cennik

A-912

7-Aminoflunitrazepam solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

A-921

7-Aminoflunitrazepam-d₇ solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

A-925

7-Aminoflunitrazepam-d₇ solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

B-033

Benzodiazepine Multi-component Mixture-8 solution, 250 μg/mL each component in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

B-905

Benzodiazepine Internal Standard-3 solution, 0.5-1.0 mg/mL in acetonitrile, ampule of 1.0 mL, certified reference material, Cerilliant^®

D-918

N-Desmethylflunitrazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

D-919

N-Desmethylflunitrazepam solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

D-925

N-Desmethylflunitrazepam-d₄, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

F-907

Flunitrazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

F-915

Flunitrazepam-d₇, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H302 + H312 + H332,H319

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Klasa składowania

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo.

I Gafni et al.

Journal of clinical psychopharmacology, 23(2), 169-175 (2003-03-18)

Flunitrazepam, a hypnotic benzodiazepine, is widely prescribed around the world for the treatment of insomnia and as a preanesthetic. In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic

Extraction and analysis of flunitrazepam/7-aminoflunitrazepam in blood and urine by LC-PDA and GC-MS using butyl SPE columns.

Jeffery Hackett et al.

Forensic science international, 157(2-3), 156-162 (2005-06-16)

The forensic toxicology community has recognized flunitrazepam and its metabolite (7-aminoflunitrazepam) as compounds of concern for several years. In this procedure, the analytes were extracted from whole blood and urine onto single mode solid phase cartridges (butyl) using nitrazepam as

Sweeping technique combined with micellar electrokinetic chromatography for the simultaneous determination of flunitrazepam and its major metabolites.

Chiung-Wei Huang et al.

Journal of chromatography. A, 1110(1-2), 240-244 (2006-02-18)

A sweeping technique, in conjunction with micellar electrokinetic chromatography, for the simultaneous determination of flunitrazepam and its major metabolites, 7-aminoflunitrazepam and N-desmethylflunitrazepam, is described. The optimized conditions for the sweeping and separation were a pH 9.5 buffer, 25mM borate, 50mM

Development of immunoaffinity solid phase microextraction probes for analysis of sub ng/mL concentrations of 7-aminoflunitrazepam in urine.

H L Lord et al.

Journal of pharmaceutical and biomedical analysis, 40(3), 769-780 (2005-12-15)

We report on the development of solid phase microextraction probes for drug analysis, prepared with antibodies specific for benzodiazepines covalently immobilized to the surface. In the technique, immobilized antibody probes are exposed to a sample containing the drug for 30

Nanoparticle-assisted MALDI-TOF MS combined with seed-layer surface preparation for quantification of small molecules.

Yi-Chi Ho et al.

Analytica chimica acta, 697(1-2), 1-7 (2011-06-07)

Despite the advantages of simplicity and high-throughput detection that matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has over other methods, quantitative analysis of low-molecular-weight analyte is hampered by interference from matrix-derived background noise and signal fluctuation due to the

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