890701P
Avanti
14:0 EPC (Cl Salt)
Avanti Research™ - A Croda Brand
Synonim(y):
1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
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About This Item
Wzór empiryczny (zapis Hilla):
C38H77NO8PCl
Numer CAS:
Masa cząsteczkowa:
742.45
Kod UNSPSC:
12352211
NACRES:
NA.25
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powder
opakowanie
pkg of 1 × 10 mg (890701P-10mg)
pkg of 1 × 25 mg (890701P-25mg)
producent / nazwa handlowa
Avanti Research™ - A Croda Brand
typ lipidu
transfection
cationic lipids
Warunki transportu
dry ice
temp. przechowywania
−20°C
ciąg SMILES
O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)OCC.[Cl-]
Opis ogólny
1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC) is an acyl cationic lipid. O-alkyl phosphatidylcholines constitute the first chemically stable tri-esters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.
Zastosowanie
1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC (Cl Salt)) is suitable for use in liposome formulations.
Działania biochem./fizjol.
Synthetic cationic lipids serve as non-viral gene delivery agents. Change in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency. 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC) aids in hydration during the formation of liposomes.
Opakowanie
5 mL Clear Glass Sealed Ampule (890701P-10mg)
5 mL Clear Glass Sealed Ampule (890701P-25mg)
Informacje prawne
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
William P D Goldring et al.
Bioorganic & medicinal chemistry letters, 22(14), 4686-4692 (2012-06-19)
The synthesis and in vitro evaluation of four cationic lipid gene delivery vectors, characterized by acyclic or macrocyclic, and saturated or unsaturated hydrophobic regions, is described. The synthesis employed standard protocols, including ring-closing metathesis for macrocyclic lipid construction. All lipoplexes
Paria Parvizi et al.
International journal of pharmaceutics, 461(1-2), 145-156 (2013-12-04)
This study seeks correlations between the molecular structures of cationic and neutral lipids, the lipid phase behavior of the mixed-lipid lipoplexes they form with plasmid DNA, and the transfection efficacy of the lipoplexes. Synthetic cationic pyridinium lipids were co-formulated (1:1)
Emile Jubeli et al.
European journal of medicinal chemistry, 125, 225-232 (2016-09-24)
In this communication we describe the construction of four succinic-based cationic lipids, their formulation with plasmid DNA (pDNA), and an evaluation of their in vitro gene delivery into Chinese hamster ovarian (CHO-K1) cells. The cationic lipids employed in this work possess
Kervin O Evans et al.
Chemistry and physics of lipids, 220, 49-56 (2019-02-24)
The capacity of molecules to inhibit oxidation is widely tested using liposomes as host matrices of the antioxidant molecule of interest. Spectroscopic assays are readily used for this purpose, specifically assays using 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH). In this work the effect
Rumiana Koynova et al.
The journal of physical chemistry. B, 111(27), 7786-7795 (2007-06-19)
Some mixtures of two cationic lipids including phospholipid compounds (O-ethylphosphatidylcholines) as well as common, commercially available cationic lipids, such as dimethylammonium bromides and trimethylammonium propanes, deliver therapeutic DNA considerably more efficiently than do the separate molecules. In an effort to
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