800810C

10:0 DG

1,2-didecanoyl-sn-glycerol, chloroform

• Synonim(y): DG(10:0/10:0/0:0)
• Wzór empiryczny (zapis Hilla): C₂₃H₄₄O₅
• Numer CAS: 60514-49-0
• Masa cząsteczkowa: 400.59
• Kod UNSPSC: 12352211
• NACRES: NA.25

Właściwości

• Próba: >99% (TLC)
• Formularz: liquid
• opakowanie: pkg of 1 × 5 mL (800810C-10mg)
• producent / nazwa handlowa: Avanti Research^™ - A Croda Brand 800810C
• stężenie: 2 mg/mL (800810C-10mg)
• typ lipidu: neutral glycerides; neutral lipids
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• InChI: 1S/C23H44O5/c1-3-5-7-9-11-13-15-17-22(25)27-20-21(19-24)28-23(26)18-16-14-12-10-8-6-4-2/h21,24H,3-20H2,1-2H3/t21-/m0/s1
• Klucz InChI: GNSDEDOVXZDMKM-NRFANRHFSA-N

Opis

Opis ogólny

10:0 DG (DDG), also called 1,2-didecanoyl-sn-glycerol, is a substrate for human pancreatic lipase (HPL).[1]

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.[2][3][4][5]
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

Zastosowanie

10:0 DG has been used in the monomolecular film preparation for enzyme assay studies.[6] It may be used in diacylglycerol kinase (DGK) activity assay in DDT1-MF2 cells[7] and in glomerulus homogenate from diabetic rats.[8]

Opakowanie

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800810C-10mg)

Przechowywanie i stabilność

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Inne uwagi

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H315,H319,H331,H336,H351,H361d,H372
• Zwroty wskazujące środki ostrożności: P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233
• Klasyfikacja zagrożeń: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Organy docelowe: Central nervous system
• Kod klasy składowania: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): does not flash
• Temperatura zapłonu (°C): does not flash