A4926

1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid

98%

• Synonim(y): 2,2′-(Ethylenedioxy)dianiline-N,N,N′,N′-tetraacetic acid, BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid
• Wzór empiryczny (zapis Hilla): C₂₂H₂₄N₂O₁₀
• Numer CAS: 85233-19-8
• Masa cząsteczkowa: 476.43
• UNSPSC Code: 12352103
• NACRES: NA.23
• PubChem Substance ID: 57653856
• MDL number: MFCD00036255
• Beilstein/REAXYS Number: 5192406

Właściwości

• Quality Segment: 200
• assay: 98%
• form: powder
• density: ±1.494 g/cm³ at 25 °C (Predicted)
• storage temp.: 2-8°C
• SMILES string: OC(=O)CN(CC(O)=O)c1ccccc1OCCOc2ccccc2N(CC(O)=O)CC(O)=O
• InChI: 1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)
• InChI key: FTEDXVNDVHYDQW-UHFFFAOYSA-N

Opis

General description

1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) is a high-affinity, fast-acting calcium chelator for precise intracellular Ca²⁺ regulation. Its rapid binding kinetics and strong selectivity for Ca²⁺ make it essential for investigating calcium-dependent processes in neuronal and cellular research. BAPTA and its membrane-permeable derivative, BAPTA-AM, allow controlled manipulation of Ca²⁺ dynamics, facilitating studies on calcium signaling, neuroprotection, and cell signaling pathways.

Application

The product can be used in various R&D applications such as:

Neuroscience: Used to suppress intracellular Ca²⁺ overload, reduce neuronal apoptosis, and preserve electrophysiological function in injury models, demonstrating strong neuroprotective action.

Pharmacology: Enables precise buffering of intracellular Ca²⁺ levels, allowing researchers to distinguish Ca²⁺‑ dependent drug effects and dissect therapeutic signaling mechanisms.

Other Notes

pKa: 1.401 ± 0.10 (predicted)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves