545686
3-Chloro-2-methylbenzenesulfonyl chloride
97%
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Wzór liniowy:
ClC6H3(CH3)SO2Cl
Numer CAS:
Masa cząsteczkowa:
225.09
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
Assay:
97%
Pomoc techniczna
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Pozwól nam pomócassay
97%
mp
71-74 °C (lit.)
SMILES string
Cc1c(Cl)cccc1S(Cl)(=O)=O
InChI
1S/C7H6Cl2O2S/c1-5-6(8)3-2-4-7(5)12(9,10)11/h2-4H,1H3
InChI key
ZSIYKAQPQRTBPF-UHFFFAOYSA-N
General description
3-Chloro-2-methylbenzenesulfonyl chloride is an aryl sulfonyl chloride derivative.
Application
3-Chloro-2-methylbenzenesulfonyl chloride may be used in the synthesis of ethyl [6-(3-chloro-2-methyl-benzenesulfonyl-amino)-pyridin-2-yl]-acetate and ethyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate.
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signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Klasa składowania
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
P G De Benedetti et al.
Journal of medicinal chemistry, 30(3), 459-464 (1987-03-01)
A set of 25 4'-, eight 2',4'-, and five 2',4',6'-substituted 4-aminodiphenyl sulfones were tested for their inhibitory activity on dihydropteroate synthase of Escherichia coli. Linear regression analysis shows that enzymic inhibition indices correlate well with both quantum chemical and spectroscopic
Tjeerd Barf et al.
Journal of medicinal chemistry, 45(18), 3813-3815 (2002-08-23)
Novel antidiabetic arylsulfonamidothiazoles are presented that exert action through selective inhibition of the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme, thereby attenuating hepatic gluconeogenesis. The diethylamide derivative 2a was shown to potently inhibit human 11beta-HSD1 (IC(50) = 52 nM), whereas the
Michael Siu et al.
Bioorganic & medicinal chemistry letters, 19(13), 3493-3497 (2009-05-29)
N-(Pyridin-2-yl) arylsulfonamides are identified as inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), an enzyme that catalyzes the reduction of the glucocorticoid cortisone to cortisol. Dysregulation of glucocorticoids has been implicated in the pathogenesis of diabetes and the metabolic syndrome. In