375004

2,4-Thiazolidinedione

technical grade, 90%

• Synonim(y): 2,4(3H,5H)-Thiazoledione, 2,4-Dioxo-1,3-thiazolidine, 2,4-Dioxothiazolidine, 2-Hydroxy-4,5-dihydro-1,3-thiazol-4-one, Thiazole-2,4-dione, Thiazolidin-2,4-dione, Thiazolidinedione (6CI)
• Wzór empiryczny (zapis Hilla): C₃H₃NO₂S
• Numer CAS: 2295-31-0
• Masa cząsteczkowa: 117.13
• UNSPSC Code: 12352100
• NACRES: NA.22
• PubChem Substance ID: 24863353
• EC Number: 218-941-2
• Beilstein/REAXYS Number: 110700
• MDL number: MFCD00005478
• Assay: 90%

Właściwości

• grade: technical grade
• Quality Segment: 100
• assay: 90%
• mp: 125-127 °C (lit.)
• SMILES string: O=C1CSC(=O)N1
• InChI: 1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
• InChI key: ZOBPZXTWZATXDG-UHFFFAOYSA-N

Opis

General description

2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.

Application

2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)