FGFR4
fibroblast growth factor receptor 4
Synonimy:
CD334, JTK2, TKF
Gatunek:
Human FGFR4 (2264), Mouse Fgfr4 (14186), Rat Fgfr4 (25114), Zebrafish fgfr4 (100000160), domestic guinea pig Fgfr4 (100733523), naked mole-rat Fgfr4 (101700214), Domestic Rabbit FGFR4 (100355275), Horse FGFR4 (100068679), sheep FGFR4 (101120660), cow FGFR4 (317696) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(2264) Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
- Mouse(14186) fibroblast growth factor receptor 4
- Rat(25114) fibroblast growth factor receptor 4
- Zebrafish(100000160) fibroblast growth factor receptor 4
- domestic guinea pig(100733523) fibroblast growth factor receptor 4
- naked mole-rat(101700214) fibroblast growth factor receptor 4
- Domestic Rabbit(100355275) fibroblast growth factor receptor 4
- Horse(100068679) fibroblast growth factor receptor 4
- sheep(101120660) fibroblast growth factor receptor 4
- cow(317696) fibroblast growth factor receptor 4
- dog(489095) fibroblast growth factor receptor 4
- domestic cat(101100864) fibroblast growth factor receptor 4
- chicken(395603) fibroblast growth factor receptor 4
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-FGFR4 Antibody, clone 3A11, ,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
Przeciwciało anty-FGFR-4, klon 29.2, culture supernatant, clone 29.2, from rabbit,
Reaktywność gatunkowa
human
Zastosowanie
flow cytometry
Przeciwciało anty-FGFR4, klon 2C4E1, królicze monoklonalne, ,
Reaktywność gatunkowa
mouse
Zastosowanie
immunohistochemistry
western blot
western blot
Monoclonal Anti-FGFR4 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
western blot
Anti-FGFR4 (N-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Numer produktu
Opis
Gatunek
Białko FGFR4, aktywne, 10 µg, Active, N-terminal, His6-tagged, recombinant, human FGFR4 amino acids 442-755, for use in Kinase Assays.,
Gatunek
human