BRCA2
breast cancer 2, early onset
Synonimy:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
Gatunek:
Human BRCA2 (675), Mouse Brca2 (12190), Rat Brca2 (360254), domestic guinea pig Brca2 (100713136), Zebrafish brca2 (566758), naked mole-rat Brca2 (101698015), chicken BRCA2 (374139), sheep BRCA2 (101109980), fruit fly Brca2 (37916), cow BRCA2 (507069) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(675) Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
- Mouse(12190) breast cancer 2
- Rat(360254) breast cancer 2, early onset
- domestic guinea pig(100713136) breast cancer 2, early onset
- Zebrafish(566758) breast cancer 2, early onset
- naked mole-rat(101698015) breast cancer 2, early onset
- chicken(374139) breast cancer 2, early onset
- sheep(101109980) breast cancer 2, early onset
- fruit fly(37916) Breast cancer 2, early onset homolog
- cow(507069) breast cancer 2, early onset
- dog(474180) breast cancer 2, early onset
- domestic cat(493878) breast cancer 2, early onset
- Horse(100064578) breast cancer 2, early onset
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-BRCA2 Antibody, clone 5.23, clone 5.23, Upstate®, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
immunocytochemistry
western blot
western blot
Anti-BRCA2 (Ab-1) Mouse mAb (2B), liquid, clone 2B, Calbiochem®,
Reaktywność gatunkowa
human
Zastosowanie
Monoclonal Anti-BRCA2 antibody produced in mouse, clone 3D12, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
western blot
Anti-BRCA2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-BRCA2 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, rat
Zastosowanie
ELISA
immunohistochemistry
immunohistochemistry