BRCA1
breast cancer 1, early onset
Synonimy:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Gatunek:
Human BRCA1 (672), Mouse Brca1 (12189), Rat Brca1 (497672), domestic cat BRCA1 (101081937), domestic guinea pig Brca1 (100722339), naked mole-rat Brca1 (101705460), sheep BRCA1 (101108584), Domestic Rabbit BRCA1 (100347269), cow BRCA1 (353120), domestic cat BRCA1 (493761) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(672) Summary: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
- Mouse(12189) breast cancer 1
- Rat(497672) breast cancer 1, early onset
- domestic cat(101081937) breast cancer 1, early onset
- domestic guinea pig(100722339) breast cancer 1, early onset
- naked mole-rat(101705460) breast cancer 1, early onset
- sheep(101108584) breast cancer 1, early onset
- Domestic Rabbit(100347269) breast cancer 1, early onset
- cow(353120) breast cancer 1, early onset
- domestic cat(493761) breast cancer 1, early onset
- Horse(100051990) breast cancer 1, early onset
- dog(403437) breast cancer 1, early onset
- chicken(373983) breast cancer 1, early onset
- Thale Cress(827854) protein BREAST CANCER SUSCEPTIBILITY 1-like protein
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-phospho-BRCA1 (pSer1423) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-phospho-BRCA1 (pSer1423) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
immunohistochemistry
Anti-BRCA1 (Ab-1524) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-BRCA1 (Ab-1423) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-BRCA1 Antibody, clone 2C15 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse
Zastosowanie
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Kits
Numer produktu
Opis
Gatunek
CpG WIZ™ BRCA1 -Methylation specific PCR assay, Methylation-specific PCR (MSP), performed using the CpGenome DNA Modification Kit & the CpG WIZ BRCA1 Amplification Kit, permits sensitive detection of altered DNA.,
Gatunek
human