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S5265

Sigma-Aldrich

Streptolysin O from Streptococcus pyogenes

lyophilized powder, Protein ~3 % by Lowry, 25,000-50,000 U/vial

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About This Item

Número de CAS:
98072-47-0
Número CE:
308-500-3
Número MDL:
MFCD00132389
Código UNSPSC:
12352202
NACRES:
NA.85
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Formulario

lyophilized powder

Nivel de calidad

200

actividad específica

25,000-50,000 U/vial

mol peso

native 69 kDa

composición

Protein, ~3% Lowry

condiciones de almacenamiento

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white

solubilidad

H2O: soluble 1 mg/mL

espectro de actividad antibiótica

neoplastics

Modo de acción

cell membrane | interferes

temp. de almacenamiento

2-8°C

Información sobre el gen

Streptococcus pyogenes MGAS8232 ... slo(993428)

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Aplicación

Permeabilizes membranes to permit cellular uptake of large or charged molecules.
Streptolysin O is a toxin secreted by Streptococcus pyogenes and is a prototype member of poreforming bacterial cytolysins. It is used permeabilize cell membranes to permit cellular uptake of large or charged molecules. It is used to study macromolecule delivery[1]. It is a potential anticancer agent and is used to study suicide cancer gene therapy[1].
Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.

Acciones bioquímicas o fisiológicas

Streptolysin O possesses a single polypeptide chain with a molecular weight of f62 kDa. Streptolysin O binds to membrane cholesterol and oligomerizes to create a ring structure that consists of 45 to 50 units. The ring structure inserts into the membrane to make a large pore (25 to 30 nm), which DNA, RNA, peptides and proteins may pass[1]. It is thiol-activated. It is inhibited by allicin, an active component of garlic[2].
Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.
Thiol-activated toxin that permeabilizes animal cell membranes..

Envase

25KU

Definición de unidad

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

Forma física

Lyophilized powder containing Tris buffer salts, sodium azide, PMSF, and EDTA.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000404460
0000404460
0000192753
078M4091V
11180415

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Stefanie Klar et al.
Journal of occupational medicine and toxicology (London, England), 16(1), 32-32 (2021-08-14)
Workers of agriculture and intensive life stock farming are exposed to highly contaminated workplaces. Bioaerosol exposures are suspected to trigger respiratory health effects of the workers. So far, risk evaluation of bioaerosols has been assessed through the infectivity of comprising
Chen Chen et al.
Nanoscale, 10(11), 5154-5162 (2018-03-02)
Exosomes are small membrane vesicles secreted by a wide variety of cells. Studies have demonstrated that exosomal miRNAs can influence the biological processes of recipient cells. Therefore, direct imaging and tracking of exosomal miRNAs in living recipient cells are essential
Wan Seok Yang et al.
Molecular cancer therapeutics, 5(6), 1610-1619 (2006-07-05)
We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently killed 293T cells after 12 hours of transfection as determined
Neurotransmitter interactions related to central dopamine neurons.
K G Lloyd
Essays in neurochemistry and neuropharmacology, 3, 129-207 (1978-01-01)
Mohsen Arzanlou et al.
Journal of medical microbiology, 59(Pt 9), 1044-1049 (2010-06-12)
Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated the effect of allicin and aqueous garlic extracts
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