S4264
Spermine
BioReagent, suitable for cell culture
Sinónimos:
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
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About This Item
Fórmula lineal:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Número de CAS:
Peso molecular:
202.34
Beilstein:
1750791
Número CE:
Número MDL:
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
NACRES:
NA.75
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
origen biológico
microbial
synthetic
Nivel de calidad
Línea del producto
BioReagent
Ensayo
≥96%
Formulario
solid
técnicas
cell culture | mammalian: suitable
bp
150 °C/5 mmHg (lit.)
mp
28-30 (lit.)
solubilidad
H2O: 50 mg/mL
temp. de almacenamiento
2-8°C
cadena SMILES
[H]N(CCCN)CCCCN([H])CCCN
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
Clave InChI
PFNFFQXMRSDOHW-UHFFFAOYSA-N
Información sobre el gen
human ... GRIN2B(2904)
rat ... Grin2a(24409)
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Aplicación
Spermine has been used:
- in the buffer, to swap the divalent cations in the MgSO4 protocol to stabilize the integrity of the chromosomes[1]
- in the preparation of modified mica surfaces from freshly cleaved mica surfaces[2]
- to study its effects on survival in mice with sepsis and to estimate the role of spermine in lethal systemic inflammatory diseases[3]
Acciones bioquímicas o fisiológicas
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Dam. 1 - Skin Corr. 1B
Código de clase de almacenamiento
8A - Combustible corrosive hazardous materials
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Los clientes también vieron
Dong M, et al.
Journal of Immunology, 178(5), 3016-3022 (2007)
Miyuki Murata et al.
Current eye research, 42(12), 1674-1683 (2017-09-25)
Purpose/Aim of the study: To explore the possible role of vascular adhesion protein-1 (VAP-1) via its enzymatic function as a semicarbazide-sensitive amine oxidase (SSAO) in the pathogenesis of proliferative diabetic retinopathy (PDR). The levels of soluble VAP-1/SSAO and the unsaturated
Fractionation of chromosome 15 with an affinity-based approach using magnetic beads
Vitharana S N and Wilson G S
Genomics, 87(1), 158-164 (2006)
Marcin Wawrzyniak et al.
Pharmacology research & perspectives, 9(4), e00837-e00837 (2021-07-22)
Asthma is a heterologous disease that is influenced by complex interactions between multiple environmental exposures, metabolism, and host immunoregulatory processes. Specific metabolites are increasingly recognized to influence respiratory inflammation. However, the role of protein-derived metabolites in regulating inflammatory responses in
H Hosseinkhani et al.
Gene therapy, 11(2), 194-203 (2004-01-09)
Dextran-spermine cationic polysaccharide was prepared by means of reductive amination between oxidized dextran and the natural oligoamine spermine. The formed Schiff-base imine-based conjugate was reduced with borohydride to obtain the stable amine-based conjugate. The transfection efficiency of the synthetic dextran-spermine
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