The molecular weight of this product is listed on the Product Detail Page under 'About This Item' as 202.34 g/mol.
S3256
Spermine
≥97%
Sinónimos:
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
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Acerca de este artículo
Fórmula lineal:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Número CAS:
Peso molecular:
202.34
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-754-2
Beilstein/REAXYS Number:
1750791
MDL number:
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Servicio técnico
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Permítanos ayudarleQuality Segment
biological source
microbial, synthetic
description
form: solid or semisolid
assay
≥97%
bp
150 °C/5 mmHg (lit.)
mp
28-30 (lit.)
solubility
water: 50 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
[H]N(CCCN)CCCCN([H])CCCN
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChI key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
Gene Information
human ... GRIN2B(2904)
rat ... Grin2a(24409)
General description
Spermine is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.[1]
Application
Spermine has been used:
- as an inositol 1,4,5-trisphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) agonist to activate MCU in mouse podocytes
- in the biolistic transfection of filarial parasites
- for the production of adeno-associated virus (AAV)
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
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Este artículo | |||
|---|---|---|---|
| biological source microbial, synthetic | biological source microbial, synthetic | biological source microbial, synthetic | biological source - |
| assay ≥97% | assay ≥96% | assay ≥99.0% (GC) | assay ≥99.0% (GC), 97.0-103.0% (T) |
| Gene Information human ... GRIN2B(2904) | Gene Information human ... GRIN2B(2904) | Gene Information - | Gene Information - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility water: 50 mg/mL, clear, colorless | solubility H2O: 50 mg/mL | solubility water: 0.05 g/mL, clear, colorless | solubility - |
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Clase de almacenamiento
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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What is the molecular weight of this product?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is the storage temperature for the product?
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As mentioned in the PROPERTIES section of the product detail page, the storage temperature of the product is 2-8°C.
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