O5761

Osteocalcin fragment 1-49 Human

≥94% (HPLC), solid

• Fórmula empírica (notación de Hill): C₂₆₉H₃₈₁N₆₇O₈₂S₂
• Número de CAS: 136461-80-8
• Peso molecular: 5929.43
• Número MDL: MFCD03457847
• Código UNSPSC: 12352200
• NACRES: NA.32

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥94% (HPLC)
• Formulario: solid
• Nº de acceso UniProt: P02818
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... BGLAP(632)

Descripción

Amino Acid Sequence

Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]

Descripción general

Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.[1][2][3]

Calcium-binding protein found in dentin and possibly other mineralized tissues.

Aplicación

Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.[4][5]

Acciones bioquímicas o fisiológicas

Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.[1][6][7]

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable