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Merck

M5319

Sigma-Aldrich

Matrine

Sinónimos:

Matridin-15-one, Sophocarpidine

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About This Item

Fórmula empírica (notación de Hill):
C15H24N2O
Número de CAS:
Peso molecular:
248.36
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.25

Nivel de calidad

aplicaciones

metabolomics
vitamins, nutraceuticals, and natural products

temp. de almacenamiento

2-8°C

cadena SMILES

O=C1CCCC2C3CCCN4CCCC(CN12)C34

InChI

1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1

Clave InChI

ZSBXGIUJOOQZMP-JLNYLFASSA-N

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Descripción general

Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.

Aplicación

Matrine has been used:
  • to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells
  • as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells, and ovarian cancer cells
  • to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells
  • as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines

Acciones bioquímicas o fisiológicas

Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties. It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level. Matrine may also serve as an effective sedative agent. It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice. It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.
Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Visite la Librería de documentos

Peiyuan Li et al.
Frontiers in physiology, 10, 28-28 (2019-02-26)
This study mainly investigated the effect of matrine on TNBS-induced intestinal inflammation in mice. TNBS treatment caused colonic injury and gut inflammation. Matrine (1, 5, and 10 mg/kg) treatment alleviated colonic injury and gut inflammation via reducing bleeding and diarrhea
Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression.
Zhang Y, Dong Z, Jin L, et al.
Biochemical Pharmacology (2012)
Wenjing Zhou et al.
Cancer medicine, 7(9), 4729-4743 (2018-08-07)
Matrine, a traditional Chinese medicine, has recently been shown to have antitumor properties in diverse cancer cells. Here, we explored the effect of matrine on human glioblastoma multiforme (GBM) cells. Glioblastoma multiforme cell lines were treated with matrine to assess
Hyun-Ju Lee et al.
Biomolecules & therapeutics, 25(4), 390-395 (2017-02-14)
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by
Beibei Xu et al.
Cell death discovery, 3, 16096-16096 (2017-02-10)
The development of acquired resistance to pro-apoptotic antitumor agents is a major impediment to the cure of cholangiocarcinoma (CCA). Antitumor drugs inducing non-apoptotic cell death are considered as a new approach to overcome such drug resistance. Here, we reported for

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