M5319
Matrine
Sinónimos:
Matridin-15-one, Sophocarpidine
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About This Item
Fórmula empírica (notación de Hill):
C15H24N2O
Número de CAS:
Peso molecular:
248.36
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.25
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
Nivel de calidad
aplicaciones
metabolomics
vitamins, nutraceuticals, and natural products
temp. de almacenamiento
2-8°C
cadena SMILES
O=C1CCCC2C3CCCN4CCCC(CN12)C34
InChI
1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
Clave InChI
ZSBXGIUJOOQZMP-JLNYLFASSA-N
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Descripción general
Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.[1]
Aplicación
Matrine has been used:
- to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells[2]
- as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells[3], and ovarian cancer cells[4]
- to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells[5]
- as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines[6]
Acciones bioquímicas o fisiológicas
Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties.[1] It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level.[7] Matrine may also serve as an effective sedative agent.[8] It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice.[9] It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.[10]
Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Gloves
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Beibei Xu et al.
Cell death discovery, 3, 16096-16096 (2017-02-10)
The development of acquired resistance to pro-apoptotic antitumor agents is a major impediment to the cure of cholangiocarcinoma (CCA). Antitumor drugs inducing non-apoptotic cell death are considered as a new approach to overcome such drug resistance. Here, we reported for
Can Hu et al.
Acta pharmaceutica Sinica. B, 9(4), 690-701 (2019-08-07)
Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and try to
Hyun-Ju Lee et al.
Biomolecules & therapeutics, 25(4), 390-395 (2017-02-14)
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by
Longtai You et al.
Frontiers in pharmacology, 11, 01067-01067 (2020-10-13)
Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, antinociceptive, hepatoprotective, cardioprotective, and neuroprotective
Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression.
Zhang Y, Dong Z, Jin L, et al.
Biochemical Pharmacology (2012)
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