This material has been purified from a plant source. This information may be found on the lot specific Certificate of Origin. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a certificate under the ‘Certificate of Origin’ tab:
https://www.sigmaaldrich.com/product/sigma/q4951#product-documentation
Q4951
Quercetin
≥95% (HPLC), solid, flavonoid antioxidant
Sinónimos:
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,3′,4′,5,6-Pentahydroxyflavone
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About This Item
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Nombre del producto
Quercetin, ≥95% (HPLC), solid
origen biológico
synthetic (organic)
Ensayo
≥95% (HPLC)
Formulario
solid
mp
316.5 °C
solubilidad
water: practically insoluble
temp. de almacenamiento
room temp
cadena SMILES
OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1
InChI
1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
Clave InChI
REFJWTPEDVJJIY-UHFFFAOYSA-N
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Descripción general
Quercetin is a polyphenolic flavonoid, found in food including onions, asparagus, buckwheat, radish leaves, green tea, cranberry, broccoli, apple, blueberry, and coriander. Quercetin shows strong intramolecular H-binding, which contributes to the bioavailability and transport of the compound. This explains the biological multi-functional nature of the compound and allows for the formation of strong complexes, frequently with metals.[1] Quercetin inhibits cellular proliferation and minimizes DNA damage. Among its many cardiovascular protection properties, quercetin has antioxidant and antiplatelet properties as well as antiplatelet and anti-muscle cell proliferation and migration. It also enhances cardiac cell mitochondrial function and inhibits NF-κB. Numerous animal studies involving dietary quercetin supplementation have shown a protective effect against cardiac problems.[2]
Aplicación
- Quercetin has been used as an antioxidant which reversed the immunosuppressive effects of high glucose and hyperglycemic sera in type 2 diabetic patients.[3]
- It has been used as a detoxifying phytochemical in Apis mellifera.[4]
- It has been used as a positive control in DPPH (2,2- diphenyl-1-picryhydrazyl) radical scavenging assay. It has also been used for the preparation of calibration curve to determine total flavonoid content.[5]
Acciones bioquímicas o fisiológicas
Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Quercetin may also inhibit fatty acid synthase activity.
Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin may also inhibit fatty acid synthase activity.
Características y beneficios
This compound is a featured product for ADME Tox and Kinase Phosphatase research. Discover more featured ADME Tox and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Nota de preparación
This chemical is soluble in DMSO (30 mg/ml), DMF (~30 mg/ml), and ethanol (~2 mg/ml).
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 3 Oral
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Equipo de protección personal
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Certificados de análisis (COA)
Lot/Batch Number
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Artículos
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
Protocolos
Protocol for HPLC Analysis of Flavonoids on Ascentis® RP-Amide
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What is the Source of Extraction of Quercetin Q4951?
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How can I store a solution of Quercetin Q4951 30 mg/ml in DMSO?
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The long term solution stability of this material has not been determined.
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Can you provide me the HPLC Peak Sheets ?
1 answer-
The documentation you are requesting can be supplied by our Technical Service team who can assist you with further. We kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Documentation" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.
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What is the range of absorbance wavelength for this product?
1 answer-
The absorbance spectrum of this product is not determined. See the link below to a publication that may be helpful.
https://www.sciencedirect.com/science/article/pii/S0308814616307142#:~:text=In%20the%20UV%E2%80%93visible%20range,constants%20are%20ionic%20strength%20dependent.Helpful?
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what is the solubility of this product in DMSO?
1 answer-
This chemical is soluble in DMSO (30 mg/ml), DMF (~30 mg/ml), and ethanol (~2 mg/ml).
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