The solubility of (RS)-Mevalonic acid lithium salt is as follows:
1. In H2O: 100 mg/mL (648.97 mM; ultrasonic agitation required)
2.In DMSO: 50 mg/mL (324.49 mM; ultrasonic agitation required)
90469
(RS)-Mevalonic acid lithium salt
≥96.0% (GC)
Sinónimos:
(±)-MVA-Li, rac.-MVA-Li, Lithium (±)-3,5-dihydroxy-3-methyl-pentanoate, Lithium (±)-3,5-dihydroxy-3-methyl-valerate
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About This Item
Fórmula empírica (notación de Hill):
C6H11O4 · xLi+
Número de CAS:
Peso molecular:
147.15 (free acid basis)
MDL number:
UNSPSC Code:
12352107
NACRES:
NA.25
assay:
≥96.0% (GC)
form:
solid
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Quality Level
assay
≥96.0% (GC)
form
solid
composition
lithium, 2.2-4.7%
storage temp.
2-8°C
SMILES string
OC(CCO)(CC(=O)O)C
InChI
1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)
InChI key
KJTLQQUUPVSXIM-UHFFFAOYSA-N
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Biochem/physiol Actions
Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Mevalonate pathway is an important cellular metabolic pathway present in all higher eukaryotes and many bacteria. Four enzymes in mevalonate pathway, including MVK, PMK, MDD, and FPPS, play important regulatory roles in cholesterol biosynthesis and cell proliferation. The following methods
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The mevalonate pathway is a highly conserved metabolic cascade and provides isoprenoid building blocks for the biosynthesis of vital cellular products such as cholesterol or prenyl pyrophosphates that serve as substrates for the posttranslational prenylation of numerous proteins. The pathway
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The Journal of pharmacology and experimental therapeutics, 345(2), 180-188 (2013-02-22)
Tuberous sclerosis complex (TSC) is a multi-systemic syndrome caused by mutations in TSC1 or TSC2 gene. In TSC2-null cells, Rheb, a member of the Ras family of GTPases, is constitutively activated. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and block the
Adelene Ai-Lian Song et al.
PloS one, 7(12), e52444-e52444 (2013-01-10)
Isoprenoids are a large and diverse group of metabolites with interesting properties such as flavour, fragrance and therapeutic properties. They are produced via two pathways, the mevalonate pathway or the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. While plants are the richest source of
Jordi Pérez-Gil et al.
The Biochemical journal, 452(1), 19-25 (2013-04-26)
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including
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Is there any information available regarding the solubility of (RS)-Mevalonic acid lithium salt, Catalog 90469, for resuspension purposes?
1 answer-
Helpful?
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What is the recommended solution to dissolve this product in if wanting to add to cell culture media?
1 answer-
This product is not tested for solubility. However various sources state that compound is soluble in water and PBS (may require sonication), as well as DMSO.
Helpful?
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