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Documentos

Y0000878

Atropine

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

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About This Item

Fórmula empírica (notación de Hill):
C17H23NO3
Número de CAS:
51-55-8
Peso molecular:
289.37
Beilstein/REAXYS Number:
91260
MDL number:
MFCD00022622
UNSPSC Code:
41116107
PubChem Substance ID:
329831200
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

atropine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?

InChI key

RKUNBYITZUJHSG-SPUOUPEWSA-N

Gene Information

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Atropine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

1045009

Atropine sulfate, United States Pharmacopeia (USP) Reference Standard

A1400000

Atropine sulfate, European Pharmacopoeia (EP) Reference Standard

M1300000

Methylatropine bromide, European Pharmacopoeia (EP) Reference Standard

Y0000845

Atropine for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0000816

Atropine impurity B, European Pharmacopoeia (EP) Reference Standard

PHR1379

Atropine Sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

BP023

Atropine sulfate, British Pharmacopoeia (BP) Reference Standard

BP036

Benzatropine mesilate, British Pharmacopoeia (BP) Reference Standard

1044990

Atropine, United States Pharmacopeia (USP) Reference Standard

BP689

Desmethyl benzatropine hydrochloride, British Pharmacopoeia (BP) Reference Standard

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Pharmaceutics, 12(8) (2020-08-23)
Myopia is an ophthalmic condition affecting more than 1/5th of the world population, especially children. Low-dose atropine eyedrops have been shown to limit myopia evolution during treatment. However, there are currently no commercial industrial forms available and there is little
M M McCarron et al.
Pediatrics, 87(5), 694-700 (1991-05-01)
Eight pediatric accidental overdoses of diphenoxylate-atropine (Lomotil) are reported, and 28 literature cases are reviewed. This overdose is primarily an opioid intoxication, occasionally associated with atropine toxicity. Only 6 of 36 children showed signs of atropine overdose (central nervous system
Incidence, pathophysiology, and treatment of complications during dobutamine-atropine stress echocardiography.
Marcel L Geleijnse et al.
Circulation, 121(15), 1756-1767 (2010-04-21)
D Poldermans et al.
European heart journal, 18 Suppl D, D86-D96 (1997-06-01)
Cardiac events in the peri-operative phase and late after non-cardiac vascular surgery are a major cause of morbidity and mortality. Numerous tests and diagnostic strategies--usually consisting of a combination of analysis of clinical risk factors and additional non-exercise dependent stress
Peter Jones et al.
Archives of disease in childhood, 97(2), 139-144 (2011-05-31)
Bradycardia occurs during the intubation of some critically ill children as a result of vagal stimulation due to hypoxia and/or laryngeal stimulation; such 'stable' bradycardia is accompanied by selective vasoconstriction. Some induction drugs also induce bradycardia which may be accompanied
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