Yes, stoichiometric chemistry will be an appropriate method. The molecular weight can be used to calculate clindamycin in clindamycin phosphate. See the link below to review a sample Certificate of Analysis. Page 2 reports the purity of clindamycin as well as clindamycin phosphate.
https://www.sigmaaldrich.com/certificates/Graphics/COfAInfo/fluka/pdf/rtc/PHR1021_LRAD2296.pdf
PHR1021
Clindamycin Phosphate
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
Clindamycin 2-phosphate, Clindamycin 2-dihydrogen phosphate
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About This Item
Fórmula empírica (notación de Hill):
C18H34ClN2O8PS
Número de CAS:
Peso molecular:
504.96
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24
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Productos recomendados
grado
certified reference material
pharmaceutical secondary standard
Nivel de calidad
Agency
traceable to Ph. Eur. C2269000
traceable to USP 1138008
familia API
clindamycin
CofA
current certificate can be downloaded
técnicas
HPLC: suitable
gas chromatography (GC): suitable
aplicaciones
pharmaceutical (small molecule)
Formato
neat
temp. de almacenamiento
-10 to -25°C
cadena SMILES
CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O
InChI
1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1
Clave InChI
UFUVLHLTWXBHGZ-MWBQRTRKSA-N
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Descripción general
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clindamycin is a common antibiotic drug generally employed for the treatment of infections caused by gram-positive aerobes and both gram-negative and gram-positive anaerobic pathogens.[1]
Clindamycin is a common antibiotic drug generally employed for the treatment of infections caused by gram-positive aerobes and both gram-negative and gram-positive anaerobic pathogens.[1]
Aplicación
Clindamycin Phosphate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography[2] and potentiometry[3] techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Acciones bioquímicas o fisiológicas
Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Otras notas
Antibacterial and antiprotozoal antibiotic of the licosamide class.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Nota de análisis
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Nota al pie de página
To see an example of a Certificate of Analysis for this material enter LRAC4009 in the slot below. This is an example certificate only and may not be the lot that you receive.
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Los clientes también vieron
Nonisothermal stability assessment of stable pharmaceuticals: testing of a clindamycin phosphate formulation
Kipp JE and Hlavaty JJ
Pharmaceutical Research, 8(5), 570-575 (1991)
High-performance liquid chromatography of clindamycin antibiotics using tris (bipyridine)-ruthenium (III) chemiluminescence detection
Targove MA and Danielson ND
Journal of Chromatographic Science, 28(10), 505-509 (1990)
Sub-second adsorption for the fast sub-nanomolar monitoring of Clindamycin in its pure and pharmaceutical samples by fast Fourier transformation with the use of continuous cyclic voltammetry at an Au microelectrode in a flowing system
Norouzi P, et al.
Materials Science and Engineering, C, 28(1), 87-93 (2008)
L Babayeva et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 25(3), 328-333 (2010-07-30)
No single effective topical treatment is available for treating all pathogenic factors causing acne vulgaris (AV). Salicylic acid (SA), tretinoin (all-TRA) and clindamycin phosphate (CDP) are known to to be effective agents depending on their comedolytic and anti-inflammatory properties. To
Shao-Min Wang et al.
Rapid communications in mass spectrometry : RCM, 23(6), 899-906 (2009-02-18)
A simple high-performance liquid chromatography/electrospray ionization tandem mass spectrometric (HPLC/ESI-MS/MS) method has been developed for the rapid identification of clindamycin phosphate and its degradation products or related impurities in clindamycin phosphate injection. Detection was performed by quadrupole time-of-flight mass spectrometry
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Hello, Which factor can be used to calculate Clindamycine base in a product having a reference this standar PHR1021 Clindamycine Phosphate? Can I use the stoichiometric factor 424.98/504.96?
1 answer-
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