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56485

Sigma-Aldrich

N-Hidroxisulfosuccinimida sodium salt

≥98% (HPLC), for peptide synthesis

Sinónimos:

Sulfo-NHS, Ácido hidroxi-2,5-dioxopirrolidina-3-sulfónico sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C4H4NNaO6S
Número de CAS:
106627-54-7
Peso molecular:
217.13
Beilstein/REAXYS Number:
6359129
MDL number:
MFCD00043100
UNSPSC Code:
12352005
PubChem Substance ID:
57651582
NACRES:
NA.22
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Nombre del producto

N-Hidroxisulfosuccinimida sodium salt, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

composition

carbon, 21.57-22.68 (anhydrous)
nitrogen, 6.28-6.61 (anhydrous)

reaction suitability

reaction type: Addition Reactions

impurities

≤4% water

application(s)

peptide synthesis

functional group

imide
sulfonic acid

SMILES string

[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O

InChI

1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1

InChI key

RPENMORRBUTCPR-UHFFFAOYSA-M

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Categorías relacionadas

Application

La sal N-hidroxisulfosuccinimida de sodio es un análogo sulfonado hidrosoluble de la N-hidroxisuccinimida. Puede experimentar una reacción de acoplamiento con los ácidos carboxílicos en presencia de carbodiimidas como la 1-etil-3-(3-dimetilaminopropil)carbodiimida (EDC) para formar ésteres activos hidrófilos del N-hidroxisulfosuccinimida. Estos ésteres son útiles en los experimentos de entrecruzamiento de proteínas.[1][2]

Packaging

Frasco de vidrio sin fondo. El contenido está en el interior del cono fundido insertado.

Other Notes

El sulfo-NHS se utiliza para preparar ésteres hidrófilos activos, por ejemplo para agentes reticulantes[3][4]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
WXBF5173V
BCCM3588
BCCL3044
BCCJ9858
WXBF1499V

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N-hydroxysulfosuccinimide active esters: bis (N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers.
Staros JV
Biochemistry, 21(17), 3950-3955 (1982)
Karen S Cheung Tung Shing et al.
Scientific reports, 8(1), 12457-12457 (2018-08-22)
A direct interaction between the erythropoietin (EPOR) and the beta-common (βc) receptors to form an Innate Repair Receptor (IRR) is controversial. On one hand, studies have shown a functional link between EPOR and βc receptor in tissue protection while others
R Maydelid Trujillo-Nolasco et al.
Materials science & engineering. C, Materials for biological applications, 103, 109766-109766 (2019-07-28)
Radiosynovectomy is a technique used to decrease inflammation of the synovial tissue by intraarticular injection of a β-emitting radionuclide, such as 177Lu, which is suitable for radiotherapy due to its decay characteristics. Drug-encapsulating nanoparticles based on poly lactic‑co‑glycolic acid (PLGA)
P S Anjaneyulu et al.
International journal of peptide and protein research, 30(1), 117-124 (1987-07-01)
N-Hydroxysulfosuccinimide esters are reactive functional groups employed in a variety of protein modification reagents, especially cross-linking reagents. For these compounds, hydrolysis is the most important reaction competing for reaction of the esters with nucleophilic groups in proteins. We have employed
Eloy Povedano et al.
Scientific reports, 8(1), 6418-6418 (2018-04-25)
This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What are the storage conditions for product 56485? There are no recommended conditions. Is it Room temp?

    1 answer

    1. As mentioned in the Material Safery Data Sheet, section 7, it is recommended to store under inert gas such as argon or nitrogen. Please see the link below to review the SDS:
      https://www.sigmaaldrich.com/sds/aldrich/56485

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