M6502
6-Methylpurine
≥99%
Sinónimos:
MeP
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About This Item
Fórmula empírica (notación de Hill):
C6H6N4
Número de CAS:
Peso molecular:
134.14
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
biological source
synthetic (organic)
Quality Level
assay
≥99%
form
powder
mp
237-238 °C (lit.)
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
−20°C
SMILES string
Cc1ncnc2[nH]cnc12
InChI
1S/C6H6N4/c1-4-5-6(9-2-7-4)10-3-8-5/h2-3H,1H3,(H,7,8,9,10)
InChI key
SYMHUEFSSMBHJA-UHFFFAOYSA-N
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Application
6-Methylpurine (MeP) is a toxic adenine analog used as a bisubstrate inhibitor of enzymes that bind adenosyl moieties and which may become phosphorylated to levels that inhibit RNA and protein synthesis.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Manuel Ellermann et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(23), 6369-6381 (2011-05-04)
L-Dopa, the standard therapeutic for Parkinson's disease, is inactivated by the enzyme catechol-O-methyltransferase (COMT). COMT catalyzes the transfer of an activated methyl group from S-adenosylmethionine (SAM) to its catechol substrates, such as L-dopa, in the presence of magnesium ions. The
T Nobori et al.
Biochemical and biophysical research communications, 137(3), 998-1005 (1986-06-30)
Patients with 2,8-dihydroxyadenine urolithiasis are either completely or partially deficient in adenine phosphoribosyltransferase activities. Patients with partial enzyme deficiencies, all of whom have been found among Japanese, are homozygotes having a unique mutant adenine phosphoribosyltransferase gene (APRT*J) in double dose
B W Hughes et al.
The Journal of biological chemistry, 273(4), 2322-2328 (1998-01-27)
Expression of Escherichia coli purine nucleoside phosphorylase (PNP) activates prodrugs and kills entire populations of mammalian cells, even when as few as 1% of the cells express this gene. This phenomenon of bystander killing has been previously investigated for herpes
N Kamatani et al.
Metabolism: clinical and experimental, 34(2), 164-168 (1985-02-01)
Among three unrelated patients with recurrent 2,8-dihydroxyadenine urolithiasis, two completely lacked adenine phosphoribosyltransferase (APRT) in both erythrocytes and proliferative T cells. The third patient possessed significant enzyme activities in both hemolysates and T-cell extracts at levels comparable to heterozygotes for
Theodoros Potouridis et al.
BMC chemistry, 13(1), 70-70 (2019-08-07)
Parabens and sorbic acid are commonly used as food preservatives due to their antimicrobial effect. However, their use in foods for infants and young children is not permitted in the European Union. Previous studies found these compounds in some gel-filled
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