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Merck

394882

Sigma-Aldrich

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

>97%

Sinónimos:

MTBSTFA

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About This Item

Fórmula lineal:
CF3CON(CH3)Si(CH3)2C(CH3)3
Número de CAS:
Peso molecular:
241.33
Beilstein:
3606546
Número MDL:
Código UNSPSC:
12352001
ID de la sustancia en PubChem:
NACRES:
NA.22
En este momento no podemos mostrarle ni los precios ni la disponibilidad

grado

derivatization grade

Nivel de calidad

Ensayo

>97%

Formulario

liquid

índice de refracción

n20/D 1.402 (lit.)

bp

172-175 °C (lit.)

densidad

1.036 g/mL at 25 °C (lit.)

grupo funcional

amine
fluoro

temp. de almacenamiento

2-8°C

cadena SMILES

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

Clave InChI

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

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Descripción general

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a highly reactive silylating reagent commonly used for silyation of carboxylic acids, alcohols, amines, and thiols. It is also used as a protection, deprotection reagent. [1]

Aplicación

N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) can be used:
  • As a derivatizing agent in the GC-MS analysis of hydroxylated fluorenes and in the GC analysis of amino acids. [2]
  • As an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides.
  • To functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups.[3][4][5]
MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization.

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Pictogramas

Flame

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Flam. Liq. 3

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

113.0 °F - closed cup

Punto de inflamabilidad (°C)

45 °C - closed cup

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Chemical Physics Letters, 368(1-2), 121-124 (2003)
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Two stage derivatization with N-(tert.-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) and N-methyl-bis-(trifluoroacetamide)(MBTFA) for the gas-chromatographic analysis of OH-, SH-and NH-compounds
Schoene K, et al.
Fresenius Journal of Analytical Chemistry, 348(5-6), 364-370 (1994)

Artículos

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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