L3382
Lectin from Helix pomatia
lyophilized powder, salt, free
Synonym(s):
Helix pomatia agglutinin, HPA
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1 MG
€199.00
5 MG
€668.00
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1 MG
€199.00
5 MG
€668.00
About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
€199.00
Please contact Customer Service for Availability
Recommended Products
form
lyophilized powder
Quality Level
potency
<4 μg per mL agglutination activity
impurities
salt, free
storage temp.
−20°C
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General description
Application
Biochem/physiol Actions
HPA has anti-A human blood group specificity and has an affinity for terminal N-acetyl-α-D-galactosaminyl residues. Conjugates are prepared from affinity purified lectin.
Lectin from Helix pomatia protects fertilized eggs by coating them with perivitelline fluid.[2] They exhibit antibacterial activities and immunity in snail.[2] Helix pomatia agglutinin (HPA) possess the potential to agglutinate pathogens.[1] HPA has also emerged as a marker of altered Oglycosylation in cancer.[5]
Preparation Note
Affinity purified by a modification of the method of Hammarstrom and Kabat.[6]
Analysis Note
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human blood group A erythrocytes after 1 hour incubation at 25 °C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Characterization of bovine and human group B streptococci isolated in Turkey
Ekin IH and Gurturk K
Journal of Medical Microbiology, 55(5), 517-521 (2006)
Binding of aberrant glycoproteins recognizable by Helix pomatia agglutinin in adrenal cancers
Parameswaran R, et al.
BJS open, 2(5), 353-359 (2018)
Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients
Reily C, et al.
Biotechniques, 65(2), 71-77 (2018)
Katie Barr et al.
Transfusion, 55(1), 129-136 (2014-07-22)
The FORS blood group system (originally recognized as the Apae phenotype) was discovered by sporadic activity against polyclonal anti-A reagents and activity against the lectin Helix pomatia. The extent of monoclonal anti-A reagent activity against the FORS1 antigen is serologically
Hammarstrom, S., and Kabat, E.A.
Biochemistry, 95, 311-311 (1978)
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