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244309

Sigma-Aldrich

Ethyl β-carboline-3-carboxylate

97%

Synonym(s):

β-CCE, Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C14H12N2O2
CAS Number:
74214-62-3
Molecular Weight:
240.26
MDL number:
MFCD00009730
UNSPSC Code:
12352100
PubChem Substance ID:
24854665
NACRES:
NA.22

Assay

97%

form

solid

mp

228-230 °C (lit.)

functional group

ester

SMILES string

CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

InChI key

KOVRZNUMIKACTB-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRG2(2566)
rat ... Gabra2(29706)

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBV6762V
MKBN4714V
MKBH6160V
MKBB4707V
MKBB4707

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D B Williams et al.
Molecular pharmacology, 58(5), 1129-1136 (2000-10-20)
Benzodiazepine binding to gamma-aminobutyric acid type A (GABA(A)) receptors allosterically modulates GABA binding and increases the currents induced by submaximal GABA concentrations. Benzodiazepines induce conformational changes in the GABA-binding site in the extracellular domain, but it is uncertain whether these
L R Gerak et al.
Pharmacology, biochemistry, and behavior, 61(4), 375-380 (1998-11-05)
This study examined changes in ventilation produced by negative gamma-aminobutyric acid(A) (GABA(A)) modulators in rhesus monkeys. The effects of Ro 15-4513, beta-CCE and beta-CCM were examined in four rhesus monkeys breathing air or 5% CO2 in air. When monkeys breathed
Beta-carboline-3-carboxylic acid ethyl ester: a lead for new psychotropic drugs.
R Schmiechen et al.
Psychopharmacology series, 11, 7-15 (1993-01-01)
M Yasui et al.
Neuropharmacology, 32(2), 127-131 (1993-02-01)
The effects of benzodiazepine inverse agonists on the long-term potentiation of synaptic transmission in hippocampal slices of the guinea pig were examined using an extracellular recording technique. Benzodiazepine inverse agonists, beta-carboline-3-carboxylate (beta-CCE), 2-phenylpyrazolo [4,3-c]quinolin-3(5H)-one (CGS-8216) and 2-[5-methylthien-3-yl]-2,5-dihydro-3H-pyrazolo [4,3-c]quinolin-3-one (S-135), augmented
B K Koe et al.
European journal of pharmacology, 90(1), 97-102 (1983-05-20)
Ethyl beta-carboline-3-carboxylate (beta CCE), a benzodiazepine antagonist, was found to increase basal levels of cyclic GMP in rat cerebellum. beta CCE also augmented the elevation of cyclic GMP concentrations induced by isoniazid, in contrast to diazepam which blocked this effect
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