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C7956

Sigma-Aldrich

Coenzyme Q1

≥95%

Sinónimos:

2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone, Ubiquinone-1, Ubiquinone-5

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2 MG
MXP 2,957.00
10 MG
MXP 7,785.00
5 X 10 MG
MXP 31,307.00

MXP 2,957.00


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2 MG
MXP 2,957.00
10 MG
MXP 7,785.00
5 X 10 MG
MXP 31,307.00

About This Item

Fórmula empírica (notación de Hill):
C14H18O4
Número de CAS:
Peso molecular:
250.29
Número MDL:
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
NACRES:
NA.51

MXP 2,957.00


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Ensayo

≥95%

Formulario

liquid

temp. de almacenamiento

−20°C

cadena SMILES

COC1=C(OC)C(=O)C(C\C=C(\C)C)=C(C)C1=O

InChI

1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3

Clave InChI

SOECUQMRSRVZQQ-UHFFFAOYSA-N

Categorías relacionadas

Descripción general

Coenzyme Q (CoQ) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. It is a ubiquinone homolog with a short isoprenoid side chain.[1]

Aplicación

Coenzyme Q1 has been used to measure the mitochondrial respiratory chain complex 1 activity.[2][3][4][5]

Acciones bioquímicas o fisiológicas

Coenzyme Q1 (CoQ1) is a 1 isoprenyl group (not naturally occurring) member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes where they perform multiple functions such as electron and proton transport. The most well studied CoQ compound is CoQ10. CoQ1 is frequently used in comparison studies on the effect of isoprenyl chain length on CoQ functions or distribution and to identify quinone reductases.

Otras notas

Analog of coenzyme Q10 (not naturally occurring)

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Giancarlo A Biagini et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(21), 8298-8303 (2012-05-09)
There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during their clinical use. A failure
Lee R Swem et al.
The Journal of biological chemistry, 281(10), 6768-6775 (2006-01-13)
Rhodobacter capsulatus regulates many metabolic processes in response to the level of environmental oxygen and the energy state of the cell. One of the key global redox regulators of the cell's metabolic physiology is the sensor kinase RegB that controls
Kenichi Okamura et al.
Journal of pharmacological sciences, 141(1), 56-63 (2019-10-16)
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respiration is critically important for
P G Elmberger et al.
Lipids, 24(11), 919-930 (1989-11-01)
An effective system for perfusing rat liver using complete tissue culture medium and washed calf erythrocytes as oxygen carriers was devised. Infusion of taurocholate and glucose proved necessary to maintain stable metabolic activity and bile secretion during a 6-hr period.
R Laaksonen et al.
Clinical pharmacology and therapeutics, 57(1), 62-66 (1995-01-01)
Statins, which are commonly used drugs for hypercholesterolemia, inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. Important nonsterol compounds, such as ubiquinone, are also derived from the same synthetic pathway. Therefore it has been hypothesized that statin

Questions

1–2 of 2 Questions  
  1. What is the concentration?

    1 answer
    1. Product C7956 may present as a viscous liquid. Although a specific density has not been assigned due to the product being packaged by weight, there is a predicted density for this compound which is approximately 1.10 ±0.1 g/mL. This implies that for every 10 mg of material, the volume is expected to be around 9.1 µL. The molecular weight of this product is 250.29 g/mol, resulting in a concentration of roughly 4.39 M.

      Helpful?

  2. Hi, I use CoQ1 for COX I enzyme activity assay. Can this Coenzyme Q1(C7956) dissolve in water?

    1 answer
    1. We have only tested this item's solubility in acetone at 50 mg/ml. Upon further research, this item looks to be poorly soluble in water.

      Helpful?

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