This product may be reconstituted in water to a concentration of 0.1-1.0 mg/mL, do not vortex. For long-term storage, we recommend that the stock solution be further diluted in a buffer containing 0.1% BSA or a similar carrier protein. Store in working aliquots at -20°C to -80°C, and avoid repeated freeze/thaw cycles.
GF168
BMP-6 Protein, Human Recombinant
The Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily.
Sinónimos:
Bone Morphogenetic Protein 6, BMP6, VRR-1, VG-1-related protein
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.77
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Descripción general
Bone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Product Source: HEK293 Cells
Especificidad
Cross Reactivty
None
None
Aplicación
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Calidad
Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Forma física
Product is filtered through a 0.2 micron filter before lyophilization.
Almacenamiento y estabilidad
Store at -20°C for up to 6 months from date of receipt.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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