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Merck

F3004

Sigma-Aldrich

Fetuin from fetal calf serum

lyophilized powder

Sinónimos:

Fetuin from fetal calf serum

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25 MG
MXP 1,497.00
100 MG
MXP 4,360.00
250 MG
MXP 7,682.00
1 G
MXP 25,121.00

MXP 1,497.00


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25 MG
MXP 1,497.00
100 MG
MXP 4,360.00
250 MG
MXP 7,682.00
1 G
MXP 25,121.00

About This Item

Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.32

MXP 1,497.00


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origen biológico

bovine serum (fetal)

Formulario

lyophilized powder

técnicas

HPLC: suitable
MALDI-MS: suitable

impurezas

~0.2% free N-acetylneuraminic acid

Nº de acceso UniProt

temp. de almacenamiento

2-8°C

Información sobre el gen

bovine ... FETUB(504615)

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Descripción general

Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein.[1] It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa.[2] It belongs to the statin family and is synthesized principally in the liver and partially in the kidneys, placenta and the tongue.[3]

Aplicación

Fetuin from fetal bovine serum has been used:
  • as a standard glycoprotein in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and high-performance liquid chromatography-fluorescence detection analysis (HPLC-FLD)[4]
  • as a ligand in carbohydrate binding assay of pertussis toxin vaccine[5]
  • in the synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) for drug carrier studies[6]

Acciones bioquímicas o fisiológicas

In humans, polymorphism in the fetuin gene is implicated in type 2 diabetes mellitus and modulates adipocyte functionality. Elevated level of fetuin is observed in obesity and nonalcoholic fatty liver diseases (NAFLD).[2] Fetuin is a potential marker in clinical diagnosis of metabolic disorders.[7]

Nota de preparación

Further processing of F2379 by gel filtration.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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Fast purification of glycans and glycopeptides using silk-packed micropipette tip for matrix-assisted laser desorption/ionization-mass spectrometry and high-performance liquid chromatography-fluorescence detection analysis
Kayili H, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 139(2), 492-499 (2018)
Iqra Munir et al.
International journal of biological macromolecules, 101, 131-145 (2017-03-23)
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A was purified to highest purity and monodispersity. Green synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) has been performed giving typical
Development of an in vitro Biochemical Assay System for the Measurement of Residual Toxin Activities in Pertussis Toxin Containing Vaccines
Ting Yuen C, et al.
Journal of vaccines & vaccination, 08 (2017)
M Demetriou et al.
The Journal of biological chemistry, 271(22), 12755-12761 (1996-05-31)
The serum glycoprotein fetuin is expressed during embryogenesis in multiple tissues including limb buds and has been shown to promote bone remodeling and stimulate cell proliferation in vitro. In this report, we demonstrate that fetuin antagonizes the antiproliferative action of
A C Araujo et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 41(4), 571-578 (1993-04-01)
We investigated the localization of carbohydrate residues on the surface structures of microfilariae of Wuchereria bancrofti and Brugia malayi, using a panel of 10 different gold-labeled lectins and chitinase. The sheath, a structure that encloses the microfilariae, is not a

Questions

  1. 製品にFetuin-Aが含まれることはありますでしょうか?

    1 answer
    1. This product is native fetuin isolated from fetal bovine serum and should contain both Fetuin A and B. The percentage of each is not determined. It is prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947). The article indicates that the preparation was carried out to obtain both alpha and beta forms of Fetuin. For more information, see https://pubmed.ncbi.nlm.nih.gov/20286396/

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