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176974

Sigma-Aldrich

2,4-Dihydroxypyridine

97%

Sinónimos:

2,4-Pyridinediol, 3-Deazauracil, 4-Hydroxy-2-pyridone

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About This Item

Fórmula empírica (notación de Hill):
C5H5NO2
Número de CAS:
626-03-9
Peso molecular:
111.10
Beilstein/REAXYS Number:
108533
EC Number:
210-924-8
MDL number:
MFCD00006273
UNSPSC Code:
12352100
PubChem Substance ID:
24850611

assay

97%

form

solid

mp

272-276 °C (lit.)

SMILES string

Oc1ccnc(O)c1

InChI

1S/C5H5NO2/c7-4-1-2-6-5(8)3-4/h1-3H,(H2,6,7,8)

InChI key

ZEZJPIDPVXJEME-UHFFFAOYSA-N

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General description

2,4-Dihydroxypyridine (3-deazauracil) is a potent inhibitor of dihydrouracil dehydrogenase.

Application

2,4-Dihydroxypyridine (3-deazauracil) was used in the synthesis of diazaphenoxathiin skeleton.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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2,4-Quinolinediol 97%

Sigma-Aldrich

Q1336

2,4-Quinolinediol

4-Hydroxypyridine 95%

Sigma-Aldrich

120618

4-Hydroxypyridine

2-Aminopyridine ≥99%

Sigma-Aldrich

A77989

2-Aminopyridine

Paladio sobre carbono extent of labeling: 10 wt. % loading, matrix activated carbon support

Sigma-Aldrich

205699

Paladio sobre carbono

J Molgó et al.
Journal de pharmacologie, 16 Suppl 2, 109-144 (1985-01-01)
In this review the effects of aminopyridines and chemically related compounds are documented in an attempt to analyse the mechanism underlying their presynaptic actions at the vertebrate neuromuscular junction. Aminopyridines and related compounds are of particular interest because they greatly
K T Lin et al.
Therapeutic drug monitoring, 5(4), 491-496 (1983-01-01)
A rapid and simple procedure for liquid chromatographic analysis of plasma 3-deazauridine (3-DU), an antineoplastic agent, was developed. The plasma was extracted with methanolic silver acetate to remove interfering ultraviolet-absorbing materials and the 3-DU partially purified on a small anion
Maria Teresa Cocco et al.
European journal of medicinal chemistry, 38(1), 37-47 (2003-02-21)
Bis(pyridyl)methane derivatives 5-40 were obtained from the reaction of 4-hydroxy-2-pyridones 3 and 4 with aldehydes. Compounds 5-40 were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them
M T Cocco et al.
European journal of medicinal chemistry, 35(5), 545-552 (2000-07-12)
4-hydroxy-2-pyridone derivatives 2 were prepared by reaction of 3-amino-3-dialkylaminopropenoates with bis(2,4, 6-trichlorophenyl)malonate. These compounds were further reacted with a set of aldehydes to give bis(pyridyl)methanes 3 and 4. The newly synthesized compounds 2, 3 and 4 were evaluated in vitro
F P LaCreta et al.
Cancer research, 49(10), 2567-2573 (1989-05-15)
The breakdown of 5-fluoro-2'-deoxyuridine (FdUrd) to 5-fluorouracil (FUra) is catalyzed by the pyrimidine nucleoside phosphorylases, uridine phosphorylase and thymidine phosphorylase. The effects of nucleoside phosphorylase inhibitors on FdUrd and FUra elimination by the isolated perfused rat liver were investigated. The
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