SML2974

Apilimod

≥98% (HPLC), IL-12 and IL-23 inhibitor, powder

• Synonym(s): 3-Methyl-benzaldehyde 2-[6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone, STA 5326, STA-5326
• Empirical Formula (Hill Notation): C₂₃H₂₆N₆O₂
• CAS Number: 541550-19-0
• Molecular Weight: 418.49
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD09954108
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Apilimod, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: N4(CCOCC4)c1nc(nc(c1)N\N=C\c3cc(ccc3)C)OCCc2ncccc2
• InChI: 1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+
• InChI key: HSKAZIJJKRAJAV-KOEQRZSOSA-N

Description

Biochem/physiol Actions

Apilimod (STA-5326) is a potent, orally active and selective inhibitor of the cytokines IL-12 and IL-23. Apilimod selectively suppresses synthesis of IL-12 and IL-23 by inhibition of phosphotransferase activity of TLR-4 regulator lipid kinase PIKfyve (phosphatidylinositol-3-phosphate 5-kinase). It suppresses Th1 cells response in vivo and reduces inflammatory histopathologic changes. Also, it exhibits strong anti COVID-19 activity in two cell lines (Vero E6:IC₅₀ < 0.08 μM; A549-ACE2:IC₅₀ = 0.007 μM). Apilimod potently reduces entry of SARS-CoV S pseudovirions on 293/hACE2 cells.

potent, orally active and selective IL-12 and IL-23 inhibitor; PIKfyve inhibitor; Exhibit strong anti COVID-19 activity in cell lines

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable