Key Documents

Phentolamine hydrochloride

Name: Phentolamine hydrochloride
Brand: SIGMA

≥98% (TLC), α-adrenoceptor antagonist, powder

Synonym(s):

2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride, 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉N₃O · HCl

CAS Number:

73-05-2

Molecular Weight:

317.81

NACRES:

NA.77

PubChem Substance ID:

24898856

UNSPSC Code:

12352116

EC Number:

200-793-5

MDL number:

MFCD00079268

Beilstein/REAXYS Number:

3764617

Assay:

≥98% (TLC)

Form:

powder

Pricing and availability is not currently available.

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Properties

Product Name

Phentolamine hydrochloride, ≥98% (TLC), powder

Quality Segment

200

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

ethanol: 14 mg/mL, H₂O: 20 mg/mL, H₂O: unstable (prepare immediately prior to use)

originator

Novartis

SMILES string

Cl[H].Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H

InChI key

TUEJFGFQYKDAPM-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Biochem/physiol Actions

α-adrenoceptor antagonist; peripheral vasodilator.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Protect From Light.

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This Item	P7561	T4264	SML1507
Sigma-Aldrich P7547 Phentolamine hydrochloride	Sigma-Aldrich P7561 Phentolamine methanesulfonate salt	Sigma-Aldrich T4264 Tetrahydrozoline hydrochloride	Sigma-Aldrich SML1507 CRT0066101 hydrochloride
form powder	form powder	form -	form powder
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
solubility ethanol: 14 mg/mL, H₂O: unstable (prepare immediately prior to use), H₂O: 20 mg/mL	solubility ethanol: 26 mg/mL, H₂O: 50 mg/mL	solubility H₂O: freely soluble, alcohol: freely soluble, chloroform: very slightly soluble, diethyl ether: insoluble	solubility H₂O: 15 mg/mL, clear
color white to off-white	color white to off-white	color -	color white to beige
Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information -