Idazoxan hydrochloride

Name: Idazoxan hydrochloride
Brand: SIGMA

α2-adrenoceptor antagonist

Synonym(s):

(±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride, RX 781094

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₂N₂O₂ · HCl

CAS Number:

79944-56-2

Molecular Weight:

240.69

UNSPSC Code:

12352200

PubChem Substance ID:

24278493

NACRES:

NA.77

MDL number:

MFCD00069293

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Properties

Product Name

Idazoxan hydrochloride,

Quality Segment

100

solubility

H₂O: 50 mg/mL

SMILES string

Cl.C1CN=C(N1)C2COc3ccccc3O2

InChI

1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H

InChI key

MYUBYOVCLMEAOH-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2 imidazoline receptor agonist; I1 imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).[1]

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This Item	R9525	A0779	C7897
Sigma-Aldrich I6138 Idazoxan hydrochloride	Sigma-Aldrich R9525 RX 821002 hydrochloride	Sigma-Aldrich A0779 p-Aminoclonidine hydrochloride	Sigma-Aldrich C7897 Clonidine hydrochloride
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: 50 mg/mL	solubility H₂O: >20 mg/mL	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C), boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C), 0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C), methanol: soluble (Solutions may be stored for several days at 4 °C)	solubility H₂O: soluble, methanol: soluble
Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)