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D127

Dextrorphan tartrate

NMDA-receptor antagonist, powder

Synonym(s):

(+)-3-Hydroxy-N-methylmorphinan (+)-tartrate salt, Dextrorphan D-tartrate

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About This Item

Empirical Formula (Hill Notation):
C17H23NO · C4H6O6
CAS Number:
143-98-6
Molecular Weight:
407.46
MDL number:
MFCD00151495
UNSPSC Code:
12352200
PubChem Substance ID:
24277974
NACRES:
NA.32
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Product Name

Dextrorphan tartrate, powder

description

Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

Quality Level

200

form

powder

drug control

Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

color

white

solubility

H2O: >10 mg/mL

SMILES string

O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34

InChI

1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m10/s1

InChI key

RWTWIZDKEIWLKQ-FEBOIHDFSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

Application

Dextrorphan tartrate has been used to study its effects on blood glucose levels by targeting pancreatic islets.[1]

Biochem/physiol Actions

Dextrorphan is a noncompetitive NMDA glutamate receptor antagonist that attenuates glutamate neurotoxicity in cortical cell cultures.

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This Item
G1626PHR1974G1501
Dextrorphan tartrate powder

Sigma-Aldrich

D127

Dextrorphan tartrate

L-Glutamic acid monosodium salt hydrate ≥99% (HPLC), powder

Sigma-Aldrich

G1626

L-Glutamic acid monosodium salt hydrate

Dextrorphan tartrate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1974

Dextrorphan tartrate

L-Glutamic acid potassium salt monohydrate ≥99% (HPLC), powder

Sigma-Aldrich

G1501

L-Glutamic acid potassium salt monohydrate

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

300

form

powder

form

powder

form

powder

form

powder

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Gene Information

-

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

description

Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

description

-

description

-

description

-

solubility

H2O: >10 mg/mL

solubility

-

solubility

-

solubility

-

color

white

color

white to off-white

color

-

color

white

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000405807
0000366966
0000327663
0000405807
0000366966

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Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
Okka S, et al.
Cell Chemical Biology (2021)
A I Faden et al.
Science (New York, N.Y.), 244(4906), 798-800 (1989-05-19)
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with

Global Trade Item Number

SKUGTIN
D127-500MG04061833559222

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