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Merck

1005706

USP

冰醋酸

United States Pharmacopeia (USP) Reference Standard

别名:

乙酸, 甲烷羧酸, 冰乙酸

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About This Item

线性分子式:
CH3CO2H
CAS号:
分子量:
60.05
Beilstein:
506007
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
价格与库存信息目前不能提供

等級

pharmaceutical primary standard

蒸汽密度

2.07 (vs air)

API 家族

glacial acetic acid

自燃溫度

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

製造商/商標名

USP

技術

gas chromatography (GC): suitable

折射率

n20/D 1.371 (lit.)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

密度

1.04 g/mL at 25 °C (lit.)

應用

pharmaceutical (small molecule)

形式

neat

SMILES 字串

[F2C(F2C)13F3C]C(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI 密鑰

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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一般說明

冰醋酸是一种俗名,用于描述无水状态下的纯醋酸。它是一种透明的吸湿性弱酸,浓度通常为99.5%至100%。名称中的“冰”指的是在略低于室温的温度(16.6°C或61.9°F)下形成的冰状晶体,类似于德语术语“Eisessig”(冰-醋)。尽管被归类为弱酸,冰醋酸是一种腐蚀性毒物,在接触人体组织时,可以导致伤害甚至致命。冰醋酸的不当储存和处理会产生风险,稀释不当会导致患者受伤。[1]醋酸/醋酸酯是肽制剂中的常见反离子。[2]
冰醋酸 USP参考标准品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持,请访问现行药典网站。

應用

冰醋酸USP 参考标准用于指定质量测试和分析。它也用于制备标准溶液,用于根据美国药典(USP)通则通过液相色谱法和紫外检测器进行检测。[2]这些高度表征的物理样本直接以官方出版的专著 USP-NF 为基础,用于制药及相关行业的测试,以帮助确保肽类药物的特性、强度、质量和纯度。

更多信息请参见美国药典通则《肽中乙酸》(503- ACETIC ACID IN PEPTIDES, USP43-NF38 - 6741)。

其他說明

该产品是美国药典生物制品计划的一部分。
可能会涉及到销售限制。

相關產品

象形圖

FlameCorrosion

訊號詞

Danger

危險聲明

危險分類

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

102.2 °F - closed cup

閃點(°C)

39 °C - closed cup


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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1 of 3

ACETIC ACID IN PEPTIDES
USP43-NF38 - 6741:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(5) (2017)
Glacial Acetic Acid Adverse Events: Case Reports and Review of the Literature
Doles W, et al.
Hospital pharmacy (2015)
Acetic acid in peptides
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(5), 6741-6741 (2017)
Takashi Taniguchi et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(2), 517-526 (2014-11-12)
Fli-1, a potential predisposing factor for systemic sclerosis (SSc), is constitutively down-regulated in the lesional skin of patients with SSc by an epigenetic mechanism. To investigate the impact of Fli-1 deficiency on the induction of an SSc phenotype in various
Isabelle Brunet et al.
The Journal of clinical investigation, 124(7), 3230-3240 (2014-06-18)
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue

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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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