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13024AST

Supelco

Astec® CHIROBIOTIC® R Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 4.6 mm, HPLC Column

别名:

Chiral Recognition HPLC Column

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About This Item

分類程式碼代碼:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Astec® CHIROBIOTIC® R手性HPLC柱, 5 μm particle size, L × I.D. 25 cm × 4.6 mm

材料

stainless steel column

描述

HPLC column

產品線

Astec®

包裝

pkg of 1 ea

製造商／商標名

Astec®

參數

0-45 °C temperature
241 bar pressure (3500 psi)

技術

HPLC: suitable
LC/MS: suitable

長度 × 內徑

25 cm × 4.6 mm

基質

high-purity silica gel particle platform
fully porous particle

基質活性組

ristocetin A glycopeptide phase

粒徑

5 μm

孔徑

100 Å

工作pH值範圍

3.5-6.8

分離技術

chiral

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相关类别

一般說明

CHIROBIOTIC® R色谱柱以高纯硅胶为基质并以共价键键合了瑞斯托菌素A糖肽，已表现出适用于分离阴离子化合物对映体的特殊性能。CHIROBIOTIC ®R的选择性与有机改性剂密切相关，极其有利于醇类流动相。

  • 键合相：瑞斯西丁A
  • pH适用范围：3.5 - 6.8
  • 粒子直径：5、10或16 μm
  • 孔径：100 Å

CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献

應用


  • Sensitive Determination of Lactic Acid Isomers: The Astec® CHIROBIOTIC® R Chiral HPLC Column was crucial in a study by Henry H et al., where it facilitated the sensitive determination of D-lactic acid and L-lactic acid in urine using high-performance liquid chromatography-tandem mass spectrometry. This method is pivotal for clinical diagnostic applications, showcasing the column′s ability to resolve similar compounds that are challenging to differentiate by other means (Henry H et al., 2012).


  • Enantioseparation of Cyclopentanecarboxylic and Cyclohexanecarboxylic Acids: The column was also utilized by Berkecz R et al. to achieve high-performance liquid chromatographic enantioseparation of complex 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids. This application underscores the column′s versatility and efficacy in separating closely related chiral acids, essential for biochemical research and pharmaceutical product development (Berkecz R et al., 2009).

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法律資訊

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

應用

产品编号
说明
价格

G004409

HPLC Analysis of 2,3-Dihydroxy-3-Phenylpropionic Acid Enantiomers on CHIROBIOTIC R, application for HPLC

G004594

HPLC Analysis of Atrolactic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004667

HPLC Analysis of 2-Bromo-3-Methylbutyric Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004668

HPLC Analysis of N-(1-Phenylethyl)maleimide Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004669

HPLC Analysis of Dansyl-Glutamic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004670

HPLC Analysis of Dansyl-Leucine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004671

HPLC Analysis of Dansyl-Methionine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004672

HPLC Analysis of Dansyl-Norleucine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004673

HPLC Analysis of Dansyl-Phenylalanine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004675

HPLC Analysis of Dansyl-Valine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004676

HPLC Analysis of Alloisoleucine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004677

HPLC Analysis of FMOC-Aspartic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004678

HPLC Analysis of FMOC-Arginine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004679

HPLC Analysis of FMOC-Lysine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004680

HPLC Analysis of 3-Phenyllactic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
292188-01
292164-01
292163-01
291970-01
291931-01

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Enzyme-catalyzed synthesis of (R)- and (S)-3-hydroxy-3-(10-alkyl-10H-phenothiazin-3-yl)propanoic acids
Brem, Jurgen, et al.
Tetrahedron Asymmetry, 21 (3), 365-373 (2010)
H Henry et al.
Biomedical chromatography : BMC, 26(4), 425-428 (2011-08-16)
D-lactic acid in urine originates mainly from bacterial production in the intestinal tract. Increased D-lactate excretion as observed in patients affected by short bowel syndrome or necrotizing enterocolitis reflects D-lactic overproduction. Therefore, there is a need for a reliable and
P Dehouck et al.
Journal of chromatography. A, 1010(1), 63-74 (2003-09-25)
Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in
Enzyme-catalyzed synthesis of (R)- and (S)-3-heteroaryl-3-hydroxy-propanoic acids and their derivatives
Brem, Jurgen, et al.
Tetrahedron Asymmetry, 20 (4), 489-496 (2009)
G Bellucci et al.
Chirality, 6(3), 207-212 (1994-01-01)
The rabbit liver microsomal biotransformation of alpha-methylstyrene (1a), 2-methyl-1-hexene (1b), 2,4,4-trimethyl-1-pentene (1c), and 1,3,3-trimethyl-1-butene (1d) has been investigated with the aim at establishing the enantioface selection of the cytochrome P-450-promoted epoxidation of the double bond and the enantioselectivity of microsomal
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实验方案

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

查看所有结果

Chromatograms

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