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T9576

Sigma-Aldrich

苦鬼臼毒素

≥96% (HPLC), powder

别名:

(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, NSC 36407, PPP, Picropodophyllin

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About This Item

经验公式（希尔记法）:
C22H22O8
CAS号:
477-47-4
分子量:
414.41
MDL號碼:
MFCD01742647
分類程式碼代碼:
12352200
PubChem物質ID:
329826907
NACRES:
NA.77

品質等級

100

化驗

≥96% (HPLC)

形狀

powder

顏色

white

溶解度

DMSO: >5 mg/mL

儲存溫度

2-8°C

SMILES 字串

COc1cc(cc(OC)c1OC)[C@H]2C3C(COC3=O)[C@@H](O)c4cc5OCOc5cc24

InChI

1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1

InChI 密鑰

YJGVMLPVUAXIQN-HAEOHBJNSA-N

基因資訊

human ... IGF1R(3480)

生化／生理作用

Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable.
Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.

特點和優勢

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

品質

May contain 2-3% ethanol (w/w)

準備報告

Picropodophyllotoxin is soluble in DMSO at a concentration that is greater than 5 mg/ml.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
081M4720V
067K47114
067K47113
067K47112
067K47111

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Sigma-Aldrich

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Insulin-like Growth Factor-I human IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

I3769

Insulin-like Growth Factor-I human

Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor.
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