SML3458

KL-11743

≥98% (HPLC)

• 别名: 2-(3-(6-Ethoxy-4-((4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenyl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide, 2-[3-[6-Ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide
• 经验公式（希尔记法）: C₃₀H₃₀N₆O₃
• CAS号: 1369452-53-8
• 分子量: 522.60
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C

说明

生化／生理作用

KL-11743 is an orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo. It induces aspartate accumulation and increases mitochondrial metabolism. KL-11743 specifically inhibits the growth of tumors containing truncated the tricarboxylic acid (TCA) cycle due to mutations inactivating succinate dehydrogenase. Inhibition of glucose uptake by KL-11743 may synergize with therapies that induce oxidative stress (synthetic lethality).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable