SML3438

NDI-091143

≥90% (HPLC)

• 别名: 3-Chloro-5-[[(4,6-difluoro[1,1′-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxy-benzoic acid, methyl ester, Methyl 3-chloro-5-[(2,4-difluoro-5-phenylphenyl) sulfamoyl]-4-hydroxybenzoate, NDI 091143, NDI091143
• 经验公式（希尔记法）: C₂₀H₁₄ClF₂NO₅S
• CAS号: 2375840-87-0
• 分子量: 453.84
• MDL號碼: MFCD32644582
• 分類程式碼代碼: 51111800
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥90% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: -10 to -25°C

说明

生化／生理作用

NDI-091143 is a highly potent, allosteric ATP-citrate lyase inhibitor (human ACLY IC50 = 4.8 nM by coupled enzyme assay with 85 μM citrate; IC50 = 2.1 nM by ADP-Glo assay) that indirectly disrupts citrate binding (Ki = 7 nM) by targeting an adjacent hydrophobic site (kon = 1.02 x 10^6/M/s, koff = 0.0019/s).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable