跳转至内容
Merck
所有图片(1)

Key Documents

SML2162

Sigma-Aldrich

Telithromycin

≥90% (HPLC)

别名:

(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C43H65N5O10
分子量:
812.00
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

价格与库存信息目前不能提供

化驗

≥90% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

O=C(N1CCCCN2C=NC(C3=CC=CN=C3)=C2)O[C@]4([C@@]1([H])[C@H](C([C@@H](C[C@]([C@@H]([C@H](C([C@H](C(O[C@@H]4CC)=O)C)=O)C)O[C@H]5[C@@H]([C@H](C[C@H](O5)C)N(C)C)O)(OC)C)C)=O)C)C

InChI

1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

InChI 密鑰

LJVAJPDWBABPEJ-PNUFFHFMSA-N

生化/生理作用

Telithromycin is a ketolide antibiotic, the first to enter clinical use. It is used to treat mild to moderate respiratory infections. Telithromycin binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

STOT SE 1

標靶器官

Liver,Eyes

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

  • 技术规格说明书

  • 分析证书(COA)

    输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

    需要 COA 样本?

    这是一份质检报告(COA)样本,并不代表该特定产品的最新生产批次。

    已有该产品?

    在文件库中查找您最近购买产品的文档。

    访问文档库

    George G Zhanel et al.
    Therapeutics and clinical risk management, 2(1), 59-75 (2008-03-25)
    Acute bacterial sinusitis (ABS), acute exacerbations of chronic bronchitis (AECB), and community-acquired pneumonia (CAP) are common conditions and constitute a substantial socioeconomic burden. The ketolides are a new class of antibacterials with a targeted spectrum of antibacterial activity. In vitro
    Marema Makgatho et al.
    African health sciences, 15(4), 1271-1276 (2016-03-10)
    Malaria is on the increase due to emergence of parasite drug resistance and there is thus an urgent need for the development of new antiparasitic drugs effective at low concentrations. Ketolides antibiotics are used for treatment of various ailments and
    Pulkit Gupta et al.
    Nature chemical biology, 12(3), 153-158 (2016-01-05)
    Regulation of gene expression in response to the changing environment is critical for cell survival. For instance, binding of macrolide antibiotics to the ribosome promotes translation arrest at the leader open reading frames ermCL and ermBL, which is necessary for

    我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

    联系技术服务部门