价格与库存信息目前不能提供
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质量水平
方案
≥95% (HPLC)
表单
powder
旋光性
[α]/D -60 to -75°, c = 0.7 (CDCl3)
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
储存温度
−20°C
InChI
1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1
InChI key
NDYMQXYDSVBNLL-MUYMLXPFSA-N
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应用
生化/生理作用
Cucurbitacin E is a potent inhibitor of actin depolymerization.
Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Pei-Lin Wu et al.
Chemical & pharmaceutical bulletin, 52(3), 345-349 (2004-03-03)
Three new compounds: begonanline (1). nantoamide (2). and methyl (S)-glycerate (3). as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray
Yanmin Dong et al.
Carcinogenesis, 31(12), 2097-2104 (2010-08-25)
Cucurbitacin E (CuE, α-elaterin), a tetracyclic triterpenes compound from folk traditional Chinese medicine plants, has been shown to inhibit cancer cell growth, inflammatory response and bilirubin-albumin binding. However, the effects of CuE on tumor angiogenesis and its potential molecular mechanism
Yasuyuki Sadzuka et al.
International journal of pharmaceutics, 383(1-2), 186-191 (2009-09-08)
Cucurbitacin E increases the doxorubicin (DOX) level in M5076 ovarian sarcoma via suppressed DOX efflux in vitro. An increase in DOX induced antitumor activity by cucurbitacin E in vivo has been reported previously. This paper attempts to clarify the mechanism
Jing Qiao et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 62(5), 461-469 (2013-01-31)
Cucurbitacin E (CuE), a triterpenoid compound isolated from Cucurbitaceae plants, possesses a wide range of biological activities including anti-inflammatory properties. The present study aimed to investigate the anti-inflammatory effect of CuE and the underlying mechanism of action. The anti-inflammatory effect
Tehila Tannin-Spitz et al.
Biochemical and biophysical research communications, 364(1), 181-186 (2007-10-19)
The cucurbitacins are of great interest because of the wide range of biological activities they exhibit in plants and animals. We studied the antioxidant properties of cucurbitacin B + E glucosides (cucurbitacin glucoside combination, CGC) and their direct free-radical scavenging
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