SML0445

克立马丁 富马酸盐

≥98% (HPLC)

• 别名: (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
• 经验公式（希尔记法）: C₂₁H₂₆ClNO · C₄H₄O₄
• CAS号: 14976-57-9
• 分子量: 459.96
• EC 号: 239-055-2
• MDL编号: MFCD00137486
• UNSPSC代码: 12352200
• PubChem化学物质编号: 329824727
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 旋光性: [α]/D +15 to +25°, c = 1 in methanol
• 储存条件: desiccated
• 颜色: white to beige
• 溶解性: DMSO: 5 mg/mL (clear solution; warmed)
• 储存温度: room temp
• SMILES字符串: OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
• InChI key: PMGQWSIVQFOFOQ-YKVZVUFRSA-N
• 基因信息: human ... HRH1(3269)

说明

一般描述

Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.

应用

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.

生化/生理作用

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable