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SML0063

Sigma-Aldrich

Q-VD-OPh 水合物

≥95% (HPLC), powder, pan-caspase inhibitor

别名:

5-(2,6-二氟苯氧基)-3-[[3-甲基-1-氧代-2-[(2-喹啉基羰基)氨基]丁基]氨基]-4-氧代-戊酸 水合物

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About This Item

经验公式（希尔记法）:
C26H25F2N3O6 · xH2O
CAS号:
1435786-01-8
分子量:
513.49 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
329825128
NACRES:
NA.77

product name

Q-VD-OPh 水合物, ≥95% (HPLC)

品質等級

100

化驗

≥95% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to light brown

溶解度

DMSO: ≥14 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

O=C(NC(C(C)C)C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)=O)C2=NC3=CC=CC=C3C=C2.[H]O[H]

InChI

1S/C26H25F2N3O6.H2O/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28;/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34);1H2/t20-,23-;/m0./s1

InChI 密鑰

ONOTWLLTFZMERH-WCRWPNQISA-N

應用

Q-VD-OPh水合物已用于：
  • 作为泛胱天蛋白酶抑制剂防止细胞(UCC)死亡
  • 诱发UC细胞中典型的胱天蛋白酶依赖细胞凋亡
  • 抑制胱天蛋白酶3和多聚ADP-核糖聚合酶1(PARP-1)
  • 研究人表皮细胞中EspZ效应蛋白抗细胞凋亡和坏死的保护作用

生化／生理作用

Q-VD-OPh是一种有效的泛半胱天冬酶抑制剂，可保护细胞免于半胱天冬酶依赖性细胞凋亡。 Q-VD-OPh的水稳定性、细胞渗透性和功效优于基于FMK的半胱天冬酶抑制剂，且单用无细胞毒性。

特點和優勢

该化合物在受体分类和信号转导手册的 半胱天冬酶 页面上有详细描述。如需浏览其他手册页面，请点击此处。
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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The cyanobacterial metabolite nocuolin A is a natural oxadiazine that triggers apoptosis in human cancer cells
Voracova K, et al.
PLoS ONE, 12(3), e0172850-e0172850 (2017)
Anne Slomp et al.
Cell death & disease, 12(3), 229-229 (2021-03-05)
Multiple myeloma (MM), a treatable but incurable malignancy, is characterized by the growth of clonal plasma cells in protective niches in the bone marrow. MM cells depend on expression of BCL-2 family proteins, in particular MCL-1, for survival. The regulation
Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines
Holscher A S, et al.
Clinical epigenetics, 10(1) (2018)
Jennifer Lising Roxas et al.
Infection and immunity, 80(11), 3850-3857 (2012-08-22)
The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) limits the death of infected enterocytes early in infection. A number of bacterial molecules and host signaling pathways contribute to the enhanced survival of EPEC-infected host cells. EspZ, a type III secreted effector
Inhibition of class I histone deacetylases 1 and 2 promotes urothelial carcinoma cell death by various mechanisms
Pinkerneil M, et al.
Molecular Cancer Therapeutics, 15(2), 299-312 (2016)
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商品

半胱天冬酶抑制剂和活化剂

据报道可激活细胞半胱天冬酶的试剂包括化疗药物、TNF 受体激动剂和其他酶。细胞凋亡抑制剂是第一个确定的内源性半胱天冬酶抑制剂。

Caspases Inhibitors and Activators

Agents reported to activate cellular caspases include chemotherapeutic drugs, TNF receptor agonists, and other enzymes. Inhibitors of apoptosis were the first identified endogenous caspase inhibitors.

Caspases Inhibitors and Activators

Agents reported to activate cellular caspases include chemotherapeutic drugs, TNF receptor agonists, and other enzymes. Inhibitors of apoptosis were the first identified endogenous caspase inhibitors.

Caspases Inhibitors and Activators

Agents reported to activate cellular caspases include chemotherapeutic drugs, TNF receptor agonists, and other enzymes. Inhibitors of apoptosis were the first identified endogenous caspase inhibitors.

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