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Merck
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主要文件

SMB00610

Sigma-Aldrich

脂多糖

purified by phenol extraction

别名:

LPS

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About This Item

UNSPSC代码:
12352211
NACRES:
NA.25

生物来源

Porphyromonas gingivalis

质量水平

200

表单

powder

纯化方式

phenol extraction

杂质

≤3% Protein (Lowry)

颜色

white to faint yellow

溶解性

triethylene glycol dimethyl ether: 0.90-1.10 mg/mL to hazy, colorless to light yellow

运输

ambient

储存温度

2-8°C

相关类别

一般描述

该脂多糖(LPS)是革兰氏阴性菌（如，牙龈卟啉单胞菌）细胞壁的特征性成分。与大肠杆菌来源的脂多糖在结构和各种功能上均有所不同。

应用

脂多糖已用于：

  • 作为诱导试剂，刺激人支气管上皮(HBE)细胞产生急性肺损伤
  • 作为toll样受体4(TLR4)激动剂并刺激肠正常成纤维细胞(NF)，研究肌成纤维细胞骨桥蛋白(OPN)表达
  • 研究其对内皮细胞促炎和促凝基因表达的影响

生化/生理作用

LPS及其脂质A部分可通过Toll样受体4（TLR4）刺激先天免疫系统细胞，TLR4是Toll样受体蛋白家族的成员，它能识别常见的病原体相关分子模式（PAMP）。

此外，研究证明，大肠杆菌和牙龈卟啉单胞菌来源的脂多糖对分化簇14(CD14)、toll样受体2(TLR2)和toll样受体4(TLR4)表面表达、初次和二次细胞因子应答的调节机制各不相同。

牙龈卟啉单胞菌是革兰氏阴性菌，与成人牙周炎有关。牙周炎是一种慢性炎症，主要表现为牙周支持组织退缩。研究表明，牙龈卟啉单胞菌产生的脂多糖和牙周炎密切相关。
最近研究表明，牙龈卟啉单胞菌脂多糖可刺激胰岛β细胞株 MIN6分泌胰岛素。当存在5 mM葡萄糖和50-500 ng/mL牙龈卟啉单胞菌LPS时，观察到胰岛素分泌显著增加。

制备说明

来自牙龈卟啉单胞菌的LPS可溶于水和细胞培养基DMEM（1-5mg / mL），得到澄清溶液。

其他说明

为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000419611
0000419611
0000339813
0000339813
0000242707

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Diya Zhang et al.
Innate immunity, 14(2), 99-107 (2008-08-21)
Lipopolysaccharide (LPS) derived from the periodontal pathogen Porphyromonas gingivalis has been shown to differ from enterobacterial LPS in structure and function; therefore, the Toll-like receptors (TLRs) and the intracellular inflammatory signaling pathways are accordingly different. To elucidate the signal transduction
Epidemiology of subgingival bacterial pathogens in periodontal disease
Zambon, J. J., et al.
Molecular Pathogenesis of Periodontal Disease, 1, 1-12 (1994)
H E Barksby et al.
Clinical and experimental immunology, 156(3), 479-487 (2009-05-15)
Porphyromonas gingivalis lipopolysaccharide (LPS) (strain W50) interacts with Toll-like receptor 2 (TLR-2) leading to cytokine expression and inflammation, and thereby plays a key role in the pathogenesis of periodontal disease. The aims of this study were to investigate gene expression
Analysis of Lipopolysaccharides of Gram-Negative Bacteria
Mayer, H. et al.
Methods in Microbiology, 18, 157-207 (1985)
Epidemiology of subgingival bacterial pathogens in periodontal disease.
Zambon, J.J., et al.
Molecular Pathogenesis of Periodontal Disease, 1-12 (1994)
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