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SMB00515

Sigma-Aldrich

Afzelin

≥90% (LC/MS-UV)

别名:

3,4′,5,7-四羟基黄酮 3-鼠李糖甙, Afzeloside, 山柰酚, 山柰酚3-O-α-L-鼠李糖甙, 山柰酚3-鼠李糖甙

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About This Item

经验公式（希尔记法）:
C21H20O10
CAS号:
482-39-3
分子量:
432.38
MDL编号:
MFCD00210589
UNSPSC代码:
12352205
PubChem化学物质编号:
329825042
NACRES:
NA.25
价格与库存信息目前不能提供

方案

≥90% (LC/MS-UV)

表单

solid

溶解性

DMSO: 1 mg/mL

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

−20°C

SMILES字符串

OC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1

InChI

1S/C21H20O10/c1-8-15(25)17(27)18(28)21(29-8)31-20-16(26)14-12(24)6-11(23)7-13(14)30-19(20)9-2-4-10(22)5-3-9/h2-8,15,17-18,21-25,27-28H,1H3/t8-,15-,17+,18+,21-/m0/s1

InChI key

SOSLMHZOJATCCP-AEIZVZFYSA-N

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相关类别

一般描述

Afzelin来源于植物的天然产物。黄酮类醇苷Afzelin的主要来源为掌叶榕和香睡莲。[1]

应用

保护DNA、抗氧化、抗炎、吸收紫外线和抗菌活性。Afzelin已用于高效液相色谱法(HPLC)分析，以检测复方蒿提取物中的主要成分。[2]

生化/生理作用

Afzelin是NOS抑制剂和NADPH氧化酶抑制剂，具有抗菌、抗炎、抗凋亡和抗肿瘤活性。Afzelin可作为铜绿假单胞菌相关疾病的有效治疗药物。[3]Afzelin还能促进乳腺癌细胞凋亡，抑制细胞增殖。在小鼠模型中表现出抗哮喘作用。[1]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
122228350V
AD122228251V
122228251V

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Sigma-Aldrich

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Kashchenko N, et al.
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The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivity-guided separation led to the isolation of kaempferol 3-O-α-L-rhamnopyranoside (afzelin). The structure was determined based
Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma
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Tyrosinase enzyme is a functional oxidase that is extensively divided in nature. It is the main enzyme in melanin synthesis and is also involved in designating the color of mammalian hair and skin. Additionally, it is accountable for the unfavorable

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