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Merck
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Key Documents

SAB4504499

Sigma-Aldrich

Anti-phospho-p53 (pSer15) antibody produced in rabbit

affinity isolated antibody

别名:

Anti-BCC7, Anti-BMFS5, Anti-LFS1, Anti-P53, Anti-TRP53

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 43 kDa

物種活性

human, rat, mouse

濃度

~1 mg/mL

技術

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer15)

基因資訊

human ... TP53(7157)

一般說明

TP53 (tumor protein p53) gene is located on human chromosome 17p13.1. This is a tumor-suppressor gene.

免疫原

The antiserum was produced against synthesized peptide derived from human p53 around the phosphorylation site of Ser15.

Immunogen Range: 1-50

生化/生理作用

TP53 (tumor protein p53) gene is required for the DNA-damage checkpoint.This protein controls cell cycle, senescence and apoptosis upon oncogene activation, stress and DNA damage. Mutation in TP53 results in breast cancer.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Assessing TP53 status in human tumours to evaluate clinical outcome.
Soussi T and Beroud C
Nature Reviews. Cancer, 1(3), 233-233 (2001)
Wip1 phosphatase: between p53 and MAPK kinases pathways.
Goloudina AR, et al.
Oncotarget, 7(21), 31563-31571 (2016)
TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting.
Fountzilas G, et al.
Oncotarget, 7(22), 32731-32753 (2016)

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