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R8279

Sigma-Aldrich

RG108

≥98% (HPLC), powder

别名:

N-酞酰-L-色氨酸

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About This Item

经验公式（希尔记法）:
C19H14N2O4
CAS号:
48208-26-0
分子量:
334.33
分類程式碼代碼:
12352200
PubChem物質ID:
24724594
NACRES:
NA.77
价格与库存信息目前不能提供

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D -250 to -310°, c = 0.5 in methanol

顏色

yellow

溶解度

DMSO: >10 mg/mL

儲存溫度

−20°C

SMILES 字串

OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O

InChI

1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1

InChI 密鑰

LMAZUAXDZRILNJ-INIZCTEOSA-N

一般說明

RG108是一种非核苷类似物[1]，也称为[2-(1,3-二氧异吲哚啉-2-基)-3-(1H-吲哚-3-基)丙酸。[2]

應用

RG108可用于：
  • 重编程和提高原代多能间充质干细胞 (MMSC) 的可塑性。[3]
  • 作为人视网膜色素上皮细胞ARPE-19中的DNA甲基转移酶抑制剂 (DNMTi)。[4]
  • 作为C33A2细胞的DNA甲基转移酶抑制剂，检测其对乳头瘤病毒晚期基因表达 (HPV16) 的影响。[5]

生化／生理作用

RG108是一种DNA甲基转移酶（DMNT）抑制剂。
RG108是一种DNA甲基转移酶（DMNT）抑制剂。它通过DNA去甲基化重新激活肿瘤细胞中的肿瘤抑制基因表达（p16，SFRP1，分泌性卷曲相关蛋白-1和TIMP-3）。RG108还能抑制人肿瘤细胞系（HCT116，NALM-6）增殖并增加培养的倍增时间。
Rg108的细胞毒性低于氮杂胞苷 (5-Aza-dCR)。它介导食道癌细胞 (EC) 的辐射敏感性。[1]RG108是有效的表观遗传调控剂和去甲基化剂。[2]它不会引起细胞毒性，可用于基于人骨髓间充质干细胞 (hBMSC) 的干细胞治疗。[2]它作用于DNA甲基转移酶1的催化结构域。[4]

特點和優勢

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000201949
0000217399
125M4608V
023M4618V
030M46251V

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German Todorov et al.
Scientific reports, 9(1), 8741-8741 (2019-06-21)
Mental health disorders are manifested in families, yet cannot be fully explained by classical Mendelian genetics. Changes in gene expression via epigenetics present a plausible mechanism. Anxiety often leads to avoidant behaviors which upon repetition may become habitual, maladaptive and
Lucia Bialesova et al.
Scientific reports, 7(1), 10152-10152 (2017-09-02)
Increased adipocyte lipolysis links obesity to insulin resistance. The lipid droplet coating-protein Perilipin participates in regulation of lipolysis and is implicated in obesity. In the present study we investigate epigenetic regulation of the PLIN1 gene by correlating PLIN1 CpG methylation
Xiong Liu et al.
Cellular signalling, 51, 243-256 (2018-08-20)
It is well known that epithelial-mesenchymal transition (EMT) can confer cancer cells with invasive and migratory capabilities associated with distant metastasis. As a key upstream factor in the Hippo pathway, Kibra (wwc1 gene) has been shown to suppress EMT in
Cecilia Johansson et al.
Virology, 482, 244-259 (2015-04-23)
We report that many histone modifications are unevenly distributed over the HPV16 genome in cervical cancer cells as well as in HPV16-immortalized keratinocytes. For example, H3K36me3 and H3K9Ac that are common in highly expressed cellular genes and over exons, were
Yao Ou et al.
Oncology reports, 39(3), 993-1002 (2018-01-13)
Esophageal cancer (EC) is the eighth most common highly aggressive cancer worldwide. The purpose of this study was to investigate the effect of the DNA methyltransferase inhibitor RG108 on the radiosensitivity of EC cells. MTT and clonogenic assays were performed
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