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A2169

Sigma-Aldrich

3′-叠氮-3′-脱氧胸苷

≥98% (HPLC), powder, reverse transcriptase inhibitor

别名:

AZT, ZDV, 叠氮胸苷, 齐多夫定

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About This Item

经验公式（希尔记法）:
C10H13N5O4
CAS号:
30516-87-1
分子量:
267.24
Beilstein:
3595791
MDL號碼:
MFCD00006536
分類程式碼代碼:
12352200
PubChem物質ID:
24278143
NACRES:
NA.77

product name

3′-叠氮-3′-脱氧胸苷, ≥98% (HPLC)

化驗

≥98% (HPLC)

形狀

powder

mp

113-115 °C (lit.)

溶解度

H2O: 50 mg/mL

儲存溫度

−20°C

SMILES 字串

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI 密鑰

HBOMLICNUCNMMY-XLPZGREQSA-N

基因資訊

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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應用

3′-叠氮-3′-脱氧胸苷已作为逆转录酶抑制剂抑制病毒基因组整合和作为抗菌剂评估其抗沙门氏菌活性。

生化／生理作用

叠氮胸苷 (AZT) 是一种胸苷类似物，是 HIV-1 病毒的逆转录酶抑制剂。叠氮胸苷已被证明会降低 CRISPR 介导的同源定向修复 (HDR) 的效率。
对 HIV-1 病毒有效的逆转录酶抑制剂。

特點和優勢

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Health hazard
GHS08

訊號詞

Warning

危險聲明

H341,H351

危險分類

Carc. 2 - Muta. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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